Münster G, Bättig K
Psychopharmacologia. 1975;41(3):211-7. doi: 10.1007/BF00428926.
Nicotine, in doses of 0.15 and 0.45 mg/kg, induced hypophagia and hypodipsia in 20 hrs-deprived rats and elevated the threshold currents for hypothalamically induced feeding and drinking in satiated rats. These effects were blocked by pretreatment with 0.5 mg/kg mecamylamine, but not by pretreatment with 3.0 or 9.0 mg/kg hexamethonium. These results indicate a centrally-located mechanism for the hypophagic and hypodipsic effect of single injections of nicotine.
尼古丁剂量为0.15毫克/千克和0.45毫克/千克时，可使禁食20小时的大鼠出现摄食减少和饮水减少，并提高饱足大鼠下丘脑诱导进食和饮水的阈电流。这些作用可被0.5毫克/千克美加明预处理阻断，但不能被3.0毫克/千克或9.0毫克/千克六甲铵预处理阻断。这些结果表明单次注射尼古丁产生摄食减少和饮水减少作用的机制位于中枢。
