Schechter M D, Cook P G
Eur J Pharmacol. 1976 Jul;38(1):63-9. doi: 10.1016/0014-2999(76)90201-6.
Rats were administered 0.8 mg/kg nicotine (as base) i.p. 2 or 3 times a day for 5 weeks, and their mean body weights were observed to be significantly lower than those of control groups administered 0.9% saline on a similar regimen. The reduction in body weight after chronic nicotine administration proved highly replicable and was produced in the absence of a significant decrease in food consumption. Upon cessation of nicotine administration, the mean body weights of the rats returned to control group levels. Administration of phenylbenzoquinone, an agent that stimulated sensory pain receptors, failed to produce a similar decrease in body weight. Likewise, pretreatment with cholinergic blocking drugs, mecamylamine and hexamethonium did not antagonize the nicotine-induced decrease in body weight. Application of these results to the human smoking habit and possible mechanisms of actions are discussed.
给大鼠腹腔注射0.8mg/kg尼古丁（以碱计），每天2或3次，持续5周，观察到它们的平均体重显著低于以类似方案注射0.9%生理盐水的对照组。长期给予尼古丁后体重减轻被证明具有高度可重复性，并且在食物摄入量没有显著减少的情况下出现。停止给予尼古丁后，大鼠的平均体重恢复到对照组水平。给予刺激感觉疼痛感受器的药物苯醌未能使体重出现类似下降。同样，用胆碱能阻断药物美加明和六甲铵进行预处理并不能拮抗尼古丁引起的体重下降。本文讨论了这些结果与人类吸烟习惯的关系以及可能的作用机制。
