Clifton M J, Roux-de Balmann H, Sanchez V, Bleuzen-Mariotte V, Schoot B M
Laboratoire de Génie Chimique, Université Paul Sabatier, Toulouse, France.
J Biotechnol. 1996 Jun 27;47(2-3):341-52. doi: 10.1016/0168-1656(96)01383-1.
The RAMSES instrument is a continuous-flow electrophoresis device that performs separation and purification of biological materials on a preparative scale. It was flown on board the shuttle Columbia during the Second International Microgravity Laboratory mission that took place from 8 to 23 July 1994. This project had a technological aim to qualify the design and the technologies used, and a more scientific one to improve understanding of the phenomena involved in this process. To reach these goals, experiments were performed in which different samples and a variety of operating conditions were used, some of which cannot be applied on earth. Useful purifications were obtained, allowing samples to be collected for further analysis on the ground. These results confirm the predictions of a numerical model that could be used for future process optimization and the samples were found to have retained their biological activity.
拉姆斯仪器是一种连续流动电泳装置，可在制备规模上对生物材料进行分离和纯化。它搭载于1994年7月8日至23日进行的第二次国际微重力实验室任务期间的哥伦比亚号航天飞机上。该项目有一个技术目标，即验证所使用的设计和技术，还有一个更科学的目标，即增进对这一过程中所涉及现象的理解。为实现这些目标，进行了实验，其中使用了不同的样品和各种操作条件，其中一些条件在地球上无法应用。获得了有效的纯化结果，从而能够收集样品以便在地面进行进一步分析。这些结果证实了一个数值模型的预测，该模型可用于未来的工艺优化，并且发现样品保留了其生物活性。
