Konstantinova I V
Institute of Medical & Biological Problems of Ministry of Health of USSR, Moscow.
Acta Astronaut. 1991;23:123-7. doi: 10.1016/0094-5765(91)90108-h.
The immune system of 72 cosmonauts was studied after their flights on board Salyut 6, 7 and Mir orbital stations. PHA lymphocyte reactivity, T helper activity and NK capacity to recognize and kill the target were decreased on 1-7 days after prolonged (3-11 months) space flights. Certain alterations were found in the ultrastructure of the NK secretory and locomotor apparatuses. Decrement of IL 2 production was shown using the biological test. However immunoenzymatic analysis did not reveal a decrease in IL 2 synthesis. Production of a alpha-interferon remained unchanged while that of gamma-interferon either rose or was diminished. Several cosmonauts displayed a trend towards increased OAF production. The observed decrease in immune system functioning may increase the risk of various diseases during prolonged space flights.
对72名宇航员在搭乘“礼炮6号”、“礼炮7号”和“和平号”轨道站飞行后，研究了他们的免疫系统。在长时间（3至11个月）太空飞行后的1至7天，PHA淋巴细胞反应性、T辅助细胞活性以及NK识别和杀伤靶标的能力均有所下降。在NK分泌和运动装置的超微结构中发现了某些改变。通过生物学试验显示IL-2产量下降。然而，免疫酶分析未发现IL-2合成减少。α-干扰素的产生保持不变，而γ-干扰素的产生则要么增加要么减少。几名宇航员表现出OAF产量增加的趋势。观察到的免疫系统功能下降可能会增加长时间太空飞行期间患各种疾病的风险。
