Karim S M, Ratnam S S, Selvadural V, Wun W, Prasad R N
Prostaglandins. 1977 Feb;13(2):333-8. doi: 10.1016/0090-6980(77)90012-0.
The efficacy of 16,16 dimethyl PGE2 p-benzaldehyde semicarbazone ester for cervical dilatation prior to evacuation of the uterus in 180 first trimester nulliparae has been studied. The drug was injected into the muscle of the cervix 3 hours before vacuum aspiration. In 143 patients (80%) the cervix had dilated adequately to enable evacuation of the uterus without mechanical dilatation. In the remaining 37 patients (20%) the cervix had dilated to 6 or 7 mm and additional mechanical dilatation could be performed easily in most of these patients. Side effects consisted of vomiting (11%), diarrhoea (7%), transient pyrexia and shivering (7%). There were no complications in any of the patients and no perforation of the uterus or damage to the cervix resulted during evacuation.
研究了16,16 - 二甲基前列腺素E2对苯甲醛半卡巴腙酯在180例孕早期未产妇子宫排空术前用于宫颈扩张的疗效。在真空吸引术前3小时将药物注射到宫颈肌肉中。143例患者（80%）宫颈充分扩张，无需机械扩张即可进行子宫排空。其余37例患者（20%）宫颈扩张至6或7毫米，其中大多数患者可轻松进行额外的机械扩张。副作用包括呕吐（11%）、腹泻（7%）、短暂发热和寒战（7%）。所有患者均无并发症，子宫排空期间未发生子宫穿孔或宫颈损伤。
