Harada K, Orgel L E
The Salk Institute for Biological Studies, San Diego, CA 92186-5800, USA.
J Mol Evol. 1991;32:358-9. doi: 10.1007/BF02101274.
When arabinosyladenine-5'-phosphorimidazolide is allowed to decompose in aqueous solution at room temperature and pH 7.2, depending on the buffer, 5-24% is converted to the 2',5'-cyclic phosphate (V). Although the extent of cyclization is much greater than for adenosine-5'-phosphorimidazolide, cyclization is less efficient than hydrolysis and so would not substantially decrease the efficiency of condensation reactions in aqueous solution. The significance of this result for prebiotic chemistry is discussed.
当阿拉伯糖基腺嘌呤-5'-磷酸咪唑酯在室温及pH 7.2的水溶液中分解时，根据缓冲液的不同，有5-24%会转化为2',5'-环磷酸酯（V）。尽管环化程度比腺苷-5'-磷酸咪唑酯大得多，但环化效率低于水解效率，因此不会显著降低水溶液中缩合反应的效率。本文讨论了这一结果对前生物化学的意义。
