Tohidi M, Orgel L E
The Salk Institute for Biological Studies, San Diego, California 92138, USA.
J Mol Evol. 1990;30:97-103. doi: 10.1007/BF02099935.
When 2'-deoxythymidine-3',5'-cyclic diphosphate, or the cyclic pyrophosphates of the acyclic nucleoside analogues II and IV are heated to 65-85 degrees C in the presence of imidazole, oligomers with lengths up to 20-30 are formed in excellent yield. This reaction provides a useful source of oligomers for use as templates in aqueous condensation reactions. In the absence of evidence to the contrary, we assume that the oligomers are atactic. The potential significance of this reaction in prebiotic chemistry is discussed.
当2'-脱氧胸苷-3',5'-环二磷酸，或无环核苷类似物II和IV的环焦磷酸在咪唑存在下加热至65 - 85摄氏度时，可高产率地形成长度达20 - 30的低聚物。该反应为用作水相缩合反应模板的低聚物提供了有用的来源。在没有相反证据的情况下，我们假定这些低聚物是无规立构的。本文讨论了该反应在生命起源前化学中的潜在意义。
