右旋芬氟拉明可选择性抑制肥胖受试者对碳水化合物零食的摄取。

d-Fenfluramine selectively suppresses carbohydrate snacking by obese subjects.

作者信息

Wurtman J, Wurtman R, Mark S, Tsay R, Gilbert W, Growdon J

机构信息

Department of Applied Biology, MIT, Cambridge, MA 02139, USA.

出版信息

Int J Eat Disord. 1985;4(1):89-99. doi: 10.1002/1098-108x(198502)4:1<89::aid-eat2260040110>3.0.co;2-d.

DOI:10.1002/1098-108x(198502)4:1<89::aid-eat2260040110>3.0.co;2-d

PMID:11540865

Abstract

Twenty obese inpatients who claimed to crave carbohydrate-rich foods were given d-fenfluramine (15 mg p.o., twice daily) or its placebo, double-blind, for two consecutive eight-day periods. Food choices were measured on treatment days 1, 7, and 8 by giving the subjects access to unlimited portions of six isocaloric meal foods (three high in carbohydrate and three high in protein) and of 10 isocaloric snack foods (five high in protein and five high in carbohydrate) available 24 hours a day in a computerized vending machine. d-fenfluramine reduced mealtime calorie intake by only 16% (from 1940 +/- 94 to 1630 +/- 92; p < .001), mealtime carbohydrate by 22%, and had no significant effect on mealtime protein consumption; in contrast, snack calorie intake was reduced by 41% (from 707 +/- 97 to 414 +/- 46; p < .001), and snack carbohydrate intake by the same proportion. The mean number of carbohydrate-rich snacks consumed per day decreased from 5.8 +/- 0.8 to 3.4 +/- 0.4 (p < .01), while that of protein-rich snacks failed to change signficantly (i.e., from 0.7 +/- 0.2 to 0.5 +/- 0.2).

摘要

20名自称渴望富含碳水化合物食物的肥胖住院患者，被给予右旋芬氟拉明（口服15毫克，每日两次）或其安慰剂，采用双盲法，连续进行两个为期八天的疗程。在治疗的第1、7和8天，让受试者通过一台电脑控制的自动售货机，随意取用六种等热量膳食食物（三种高碳水化合物和三种高蛋白质）和10种等热量零食（五种高蛋白质和五种高碳水化合物），以此来测量食物选择情况。右旋芬氟拉明仅使进餐时的卡路里摄入量减少了16%（从1940±94降至1630±92；p<0.001），进餐时的碳水化合物摄入量减少了22%，而对进餐时的蛋白质摄入量没有显著影响；相比之下，零食的卡路里摄入量减少了41%（从707±97降至414±46；p<0.001），零食的碳水化合物摄入量也减少了相同比例。每天食用的富含碳水化合物零食的平均数量从5.8±0.8降至3.4±0.4（p<0.01），而富含蛋白质的零食数量没有显著变化（即从0.7±0.2降至0.5±0.2）。