含2-氨基嘌呤的寡核糖核苷酸的化学合成：用于核酶功能研究的底物
Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function.
作者信息
Doudna J A, Szostak J W, Rich A, Usman N
机构信息
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
出版信息
J Org Chem. 1990 Oct 12;55(21):5547-9. doi: 10.1021/jo00308a003.
PMID:11540922
Abstract
The chemical synthesis of a fully protected ribonucleoside phosphoramidite, containing 2-aminopurine as the base component, and its incorporation into short oligoribonucleotides as substrates for an engineered ribozyme from Tetrahymena is described.
摘要
描述了一种完全保护的核糖核苷亚磷酰胺的化学合成，该亚磷酰胺含有2-氨基嘌呤作为碱基成分，并将其掺入短寡核糖核苷酸中，作为来自嗜热四膜虫的工程核酶的底物。
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