Fritz H
Teratology. 1975 Jun;11(3):313-9. doi: 10.1002/tera.1420110310.
During the prenatal period of development of the rabbit skeleton (days 21-30) the successive phases of fetal maturity can be distinguished by reference to the progress of ossification, particularly in the distal limbs and sternum. In the present study absent or incomplete ossification of sternebra 5 occurred in 8% of term fetuses. The incidence of anomalies of prenatal ossification of the axial skeleton was 1.9%. The relevance of delayed and disturbed ossification with regard to teratological tests is discussed.
在兔骨骼发育的产前阶段（第21 - 30天），胎儿成熟的连续阶段可通过参考骨化进程来区分，尤其是在四肢远端和胸骨。在本研究中，8%的足月胎儿出现第5块胸骨节骨化缺失或不完全。轴向骨骼产前骨化异常的发生率为1.9%。讨论了骨化延迟和紊乱在致畸试验中的相关性。
