djlA基因在促进大肠杆菌生长方面与dnaJ协同发挥作用。
The djlA gene acts synergistically with dnaJ in promoting Escherichia coli growth.
作者信息
Genevaux P, Schwager F, Georgopoulos C, Kelley W L
机构信息
Département de Biochimie Médicale, Centre Médical Universitaire, Université de Genève, 1211 Genève 4, Switzerland.
出版信息
J Bacteriol. 2001 Oct;183(19):5747-50. doi: 10.1128/JB.183.19.5747-5750.2001.
Abstract
The DnaK chaperone of Escherichia coli is known to interact with the J domains of DnaJ, CbpA, and DjlA. By constructing multiple mutants, we found that the djlA gene was essential for bacterial growth above 37 degrees C in the absence of dnaJ. This essentiality depended upon the J domain of DjlA but not upon the normal membrane location of DjlA.
摘要
已知大肠杆菌的DnaK伴侣蛋白可与DnaJ、CbpA和DjlA的J结构域相互作用。通过构建多个突变体，我们发现，在缺乏dnaJ的情况下，djlA基因对于细菌在37摄氏度以上的生长至关重要。这种必要性取决于DjlA的J结构域，而不取决于DjlA的正常膜定位。
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