Morozov I S, Barchukov V G, Neznamov G G
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Eksp Klin Farmakol. 1998 Jan-Feb;61(1):30-2.
Administration of 0.05 g gidazepam once or twice daily for 7 days increased the stroke volume (SV) and circulation volume (CV) and reduced total peripheral resistance in neurotic patients. In healthy individuals 0.05 g gidazepam administered 60 min before an important examination stabilized CV. In subjects kept for 60 min in a microclimate with increasing temperature (55 +/- 2 degrees C, relative humidity 75-80%, rate of movement 1.5 m/min, rectal temperature at the end of exposure 39 degrees C) 0.05 g gidazepam administered 60 min before overheating optimally reorganized the reaction of the cardiovascular system, stabilized the SV at the initial level, which together with the growing heart rate increased the CV and provided sufficient perfusion of the vital organs. In healthy subjects working as operators for 4 h under conditions of hypercapnia (1.5% CO2), a single administration of 0.05 g gidazepam one hour before the beginning of work reduced the pulse pressure and increased the SV. The results obtained are evidence of the safety of using gidazepam as a corrector of emotion-induced disorders in operator performance under extreme conditions.
对于神经症患者，每天服用一次或两次0.05克吉地西泮，持续7天，可增加每搏输出量（SV）和循环血量（CV），并降低总外周阻力。对于健康个体，在重要检查前60分钟服用0.05克吉地西泮可稳定循环血量。在温度不断升高的微气候环境中（55±2摄氏度，相对湿度75 - 80%，移动速度1.5米/分钟，暴露结束时直肠温度39摄氏度）让受试者停留60分钟，在过热前60分钟服用0.05克吉地西泮可最佳地重组心血管系统的反应，将每搏输出量稳定在初始水平，这与心率增加一起提高了循环血量，并为重要器官提供了充足的灌注。对于在高碳酸血症（1.5%二氧化碳）条件下作为操作员工作4小时的健康受试者，在工作开始前1小时单次服用0.05克吉地西泮可降低脉压并增加每搏输出量。所获得的结果证明了在极端条件下使用吉地西泮作为操作员情绪诱发障碍校正剂的安全性。
