Lundqvist H, Jung B, Gustavsson S, Nilsson F, Lundqvist G
Acta Chir Scand. 1975;141(4):298-303.
A test substance containing 51CrO--4 was administered to the duodenum of vagotomized or sham-operated, conscious rats for 5 hours at a rate of 3.3 mul/min. The distribution of 51Cr in the stomach, small bowel, caecum and colon was measured with a scintillation counter. Data reduction was made with automatic methods. The activity distribution in the small bowel was found to be irregular. A transit time of about 3 hours was observed between the duodenum and the caecum. The proximal 40% of the small bowel was passed in about 30 min at a constant rate. No differences between vaotomized animals and controls could be demonstrated. The passage from ileum to caecum in vagotomized animals indicated a process, with constant portions, each discharge containing about 11% of the total administered activity, implying two discharges per hour.
将含51CrO--4的测试物质以3.3微升/分钟的速率注入迷走神经切断或假手术的清醒大鼠十二指肠内，持续5小时。用闪烁计数器测量51Cr在胃、小肠、盲肠和结肠中的分布。数据采用自动方法进行处理。发现小肠内的活性分布不规则。观察到十二指肠与盲肠之间的转运时间约为3小时。小肠近端40%以恒定速率在约30分钟内通过。未发现迷走神经切断动物与对照组之间存在差异。迷走神经切断动物回肠至盲肠的通过显示为一个过程，各部分恒定，每次排出物约含总给药活性的11%，意味着每小时有两次排出。
