Yoshiya K, Kishimoto T, Kusuhara K, Ishikawa Y, Utsunomiya J
Gastroenterol Jpn. 1985 Jun;20(3):197-200. doi: 10.1007/BF02774704.
To elucidate the relationship between the vagus nerve and circulating neurotensin release, mongrel dogs were given an intraduodenal infusion of a 50 ml water solution containing 10 g glucose (n = 4) or 5 g soybean oil (n = 7) over a period of 4 min before and after truncal vagotomy with pyloroplasty. In the prevagotomized animals only a slight increase of neurotensin-like immunoreactivity (NTLI) was observed following glucose infusion, while NTLI in response to fat infusion was significantly increased. After vagotomy, NTLI release following fat infusion was significantly decreased when compared to untreated control animals, suggesting that vagotomy causes a major alteration in circulating NTLI release and that the vagus nerve may play a definite role in fat-induced NTLI release.
为阐明迷走神经与循环中神经降压素释放之间的关系，在施行幽门成形术的迷走神经干切断术前及术后，给杂种犬在4分钟内十二指肠内输注含10克葡萄糖的50毫升水溶液（n = 4）或5克大豆油（n = 7）。在迷走神经切断术前的动物中，输注葡萄糖后仅观察到神经降压素样免疫反应性（NTLI）略有增加，而输注脂肪后NTLI显著增加。迷走神经切断术后，与未处理的对照动物相比，输注脂肪后的NTLI释放显著减少，这表明迷走神经切断术会导致循环中NTLI释放发生重大改变，并且迷走神经可能在脂肪诱导的NTLI释放中起明确作用。
