Department of Pediatrics, Obstetrics and Gynecology, Molecular and Integrative Physiology, and Environmental Health Sciences, The University of Michigan, 300 North Ingalls, Room 1138, Ann Arbor, MI, United States.
Steroids. 2013 Aug;78(8):734-40. doi: 10.1016/j.steroids.2013.05.004. Epub 2013 May 20.
The etiology of the polycystic ovary syndrome (PCOS) remains unclear, despite its high prevalence among infertility disorders in women of reproductive age. Although there is evidence for a genetic component of the disorder, other causes, such as prenatal insults are considered among the potential factors that may contribute to the development of the syndrome. Over the past few decades, several animal models have been developed in an attempt to understand the potential contribution of exposure to excess steroids on the development of this syndrome. The current review summarizes the phenotypes of current animal models exposed to excess steroid during the prenatal and early postnatal period and how they compare with the phenotype seen in women with PCOS.
多囊卵巢综合征（PCOS）的病因尚不清楚，尽管它在育龄妇女不孕障碍中很常见。尽管该疾病存在遗传因素的证据，但其他原因，如产前损伤等，也被认为是可能导致该综合征发生的潜在因素之一。在过去的几十年中，已经开发了几种动物模型，试图了解暴露于过量类固醇对该综合征发展的潜在贡献。本文综述了在产前和新生儿早期暴露于过量类固醇的现有动物模型的表型，以及它们与 PCOS 女性表型的比较。
