Hunter A, Vimplis S, Sharma A, Eid N, Atiomo W
Medical School, University of Nottingham, Nottingham, UK.
J Obstet Gynaecol. 2007 Aug;27(6):591-6. doi: 10.1080/01443610701497520.
The aim of this study was to determine whether first-degree male relatives of women with polycystic ovary syndrome (PCOS) were at increased risk of cardiovascular disease (CVD) and diabetes mellitus (type II DM). In a cross-sectional study, 60 women with PCOS and 112 controls were given a questionnaire. The prevalence of heart disease, stroke, diabetes and associated risk factors among fathers and brothers of women with PCOS and controls, were measured. The percentage of women with PCOS with at least one brother with a risk factor for CVD was 47.5%, around twice that seen in control women (24.71%). The prevalence of heart disease, stroke and diabetes were similar in brothers of women with PCOS and controls. In conclusion, brothers of women with PCOS may be at increased risk of CVD. They form an easily identified group, which can be targeted for primary prevention.
本研究的目的是确定多囊卵巢综合征（PCOS）女性的一级男性亲属患心血管疾病（CVD）和2型糖尿病（II型糖尿病）的风险是否增加。在一项横断面研究中，对60名患有PCOS的女性和112名对照者进行了问卷调查。测量了PCOS女性和对照者的父亲及兄弟中心脏病、中风、糖尿病及相关危险因素的患病率。患有PCOS且至少有一个兄弟存在CVD危险因素的女性比例为47.5%，约为对照女性（24.71%）的两倍。PCOS女性的兄弟与对照者的兄弟在心脏病、中风和糖尿病的患病率方面相似。总之，PCOS女性的兄弟患CVD的风险可能增加。他们构成了一个易于识别的群体，可作为一级预防的目标人群。
