Tayebi H, Lapierre V, Saas P, Lienard A, Sutton L, Milpied N, Attal M, Cahn J Y, Kuentz M, Blaise D, Hervé P, Tiberghien P, Robinet E
Laboratoire de Thérapeutique Immuno-Moléculaire, INSERM, E-0119, UPRES EA-2284, Etablissement Français du Sang-Bourgogne/Franche Comté, Besançon, France.
Br J Haematol. 2001 Sep;114(3):698-700. doi: 10.1046/j.1365-2141.2001.02965.x.
In a randomized study that compared human leucocyte antigen-identical allogeneic granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem cell (PBSC) versus bone marrow (BM) transplantation, the expression of activation markers, CD23, CD25 and CD45RO by B cells, was compared in blood before and after G-CSF mobilization and in PBSC versus BM grafts. The fractions of CD23+ and CD25+ B cells were higher in PBSC than in BM grafts. Moreover, we observed a G-CSF-induced increase in B-cell fractions in blood as well as in PBSC grafts when compared with BM grafts. Such an enhanced B-cell activation could contribute to the accelerated kinetics of immuno-haematological reconstitution, the occurrence of acute haemolysis in the ABO minor incompatibility setting, as well as the increased incidence of chronic graft-versus-host disease observed after PBSC transplantation.
