1型细胞毒素坏死因子阳性大肠杆菌在大鼠前列腺炎模型中会导致前列腺炎症加剧和组织损伤。
Cytotoxic necrotizing factor type 1-positive Escherichia coli causes increased inflammation and tissue damage to the prostate in a rat prostatitis model.
作者信息
Rippere-Lampe K E, Lang M, Ceri H, Olson M, Lockman H A, O'Brien A D
机构信息
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA.
出版信息
Infect Immun. 2001 Oct;69(10):6515-9. doi: 10.1128/IAI.69.10.6515-6519.2001.
Abstract
Infection of rat prostates with cytotoxic necrotizing factor type 1 (CNF1)-positive uropathogenic Escherichia coli caused more inflammation-mediated morphological and histological tissue damage than did infection with isogenic CNF1-negative mutants. These striking differences occurred despite the finding that bacterial counts for the strain pairs were indistinguishable. We conclude that CNF1 contributes to E. coli virulence in a model of acute prostatitis. To our knowledge, the results of this study provide the first demonstration of a role for any uropathogenic E. coli virulence factor in acute prostatitis.
摘要
用1型细胞毒性坏死因子（CNF1）阳性的尿路致病性大肠杆菌感染大鼠前列腺，比用同基因CNF1阴性突变体感染造成的炎症介导的形态学和组织学组织损伤更多。尽管发现这对菌株的细菌计数没有区别，但仍出现了这些显著差异。我们得出结论，在急性前列腺炎模型中，CNF1有助于大肠杆菌的毒力。据我们所知，本研究结果首次证明了任何尿路致病性大肠杆菌毒力因子在急性前列腺炎中的作用。
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本文引用的文献
1
Mutation of the gene encoding cytotoxic necrotizing factor type 1 (cnf(1)) attenuates the virulence of uropathogenic Escherichia coli.编码细胞毒性坏死因子1（cnf(1)）的基因突变会减弱尿路致病性大肠杆菌的毒力。
Infect Immun. 2001 Jun;69(6):3954-64. doi: 10.1128/IAI.69.6.3954-3964.2001.
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Rat model of experimentally induced abacterial prostatitis.实验性诱导无菌性前列腺炎大鼠模型
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Cytotoxic necrotizing factor type 1 of uropathogenic Escherichia coli kills cultured human uroepithelial 5637 cells by an apoptotic mechanism.尿路致病性大肠杆菌的1型细胞毒素坏死因子通过凋亡机制杀死培养的人尿道上皮5637细胞。
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Identification of the region of rho involved in substrate recognition by Escherichia coli cytotoxic necrotizing factor 1 (CNF1).鉴定大肠杆菌细胞毒素坏死因子1（CNF1）识别底物时rho蛋白所涉及的区域。
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