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1
Cytotoxic necrotizing factor type 1-positive Escherichia coli causes increased inflammation and tissue damage to the prostate in a rat prostatitis model.1型细胞毒素坏死因子阳性大肠杆菌在大鼠前列腺炎模型中会导致前列腺炎症加剧和组织损伤。
Infect Immun. 2001 Oct;69(10):6515-9. doi: 10.1128/IAI.69.10.6515-6519.2001.
2
Mutation of the gene encoding cytotoxic necrotizing factor type 1 (cnf(1)) attenuates the virulence of uropathogenic Escherichia coli.编码细胞毒性坏死因子1（cnf(1)）的基因突变会减弱尿路致病性大肠杆菌的毒力。
Infect Immun. 2001 Jun;69(6):3954-64. doi: 10.1128/IAI.69.6.3954-3964.2001.
3
The cytotoxic necrotizing factor 1 (CNF1) from uropathogenic Escherichia coli.来自尿路致病性大肠杆菌的细胞毒性坏死因子1（CNF1）。
Adv Exp Med Biol. 2000;485:45-51. doi: 10.1007/0-306-46840-9_5.
4
Lack of a role of cytotoxic necrotizing factor 1 toxin from Escherichia coli in bacterial pathogenicity and host cytokine response in infected germfree piglets.大肠杆菌细胞毒素坏死因子1毒素在感染的无菌仔猪的细菌致病性和宿主细胞因子反应中不起作用。
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5
Virulence characteristics of Escherichia coli in acute bacterial prostatitis.急性细菌性前列腺炎中大肠杆菌的毒力特征
J Infect Dis. 1999 Oct;180(4):1378-81. doi: 10.1086/314976.
6
Urovirulence determinants in Escherichia coli strains causing prostatitis.引起前列腺炎的大肠杆菌菌株中的尿路致病决定因素。
J Infect Dis. 1997 Aug;176(2):464-9. doi: 10.1086/514065.
7
The role of cytotoxic necrotizing factor-1 in colonization and tissue injury in a murine model of urinary tract infection.细胞毒性坏死因子-1在小鼠尿路感染模型中的定植及组织损伤中的作用
FEMS Immunol Med Microbiol. 2000 May;28(1):37-41. doi: 10.1111/j.1574-695X.2000.tb01454.x.
8
Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate.急性炎症促进大鼠前列腺上皮和基质细胞的早期细胞刺激。
Prostate. 2010 Aug;70(11):1153-65. doi: 10.1002/pros.21150.
9
Specific mucosal immunity in the pathophysiology of bacterial prostatitis in a rat model.
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10
Gene block encoding production of cytotoxic necrotizing factor 1 and hemolysin in Escherichia coli isolates from extraintestinal infections.编码细胞毒性坏死因子1和溶血素的基因簇在来自肠外感染的大肠杆菌分离株中的情况
Infect Immun. 1992 Jun;60(6):2182-7. doi: 10.1128/iai.60.6.2182-2187.1992.

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Preclinical models and evaluation criteria of prostatitis.前列腺炎的临床前模型和评价标准。
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The gene is associated with an expanding ST131 30Rx/C2 subclade and confers a competitive advantage for gut colonization.该基因与不断扩张的 ST131 30Rx/C2 亚群相关，为肠道定植提供了竞争优势。
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Applications of Vertebrate Models in Studying Prostatitis and Inflammation-Associated Prostatic Diseases.脊椎动物模型在前列腺炎及炎症相关前列腺疾病研究中的应用
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The Cytotoxic Necrotizing Factors (CNFs)-A Family of Rho GTPase-Activating Bacterial Exotoxins.细胞毒性坏死因子（CNFs）-一类 Rho GTPase 激活细菌外毒素。
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Crystal structure of bacterial cytotoxic necrotizing factor CNF reveals molecular building blocks for intoxication.细菌细胞毒性坏死因子 CNF 的晶体结构揭示了致毒的分子构建模块。
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Cytotoxic Necrotizing Factor 1 Downregulates CD36 Transcription in Macrophages to Induce Inflammation During Acute Urinary Tract Infections.细胞毒性坏死因子 1 通过下调巨噬细胞中 CD36 的转录来诱导急性尿路感染期间的炎症反应。
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The Bacterial Toxin CNF1 Induces Activation and Maturation of Human Monocyte-Derived Dendritic Cells.细菌毒素 CNF1 诱导人单核细胞来源的树突状细胞的活化和成熟。
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本文引用的文献

1
Mutation of the gene encoding cytotoxic necrotizing factor type 1 (cnf(1)) attenuates the virulence of uropathogenic Escherichia coli.编码细胞毒性坏死因子1（cnf(1)）的基因突变会减弱尿路致病性大肠杆菌的毒力。
Infect Immun. 2001 Jun;69(6):3954-64. doi: 10.1128/IAI.69.6.3954-3964.2001.
2
Rat model of experimentally induced abacterial prostatitis.实验性诱导无菌性前列腺炎大鼠模型
Prostate. 2000 Nov 1;45(3):201-6. doi: 10.1002/1097-0045(20001101)45:3<201::aid-pros1>3.0.co;2-q.
3
Molecular epidemiological evidence for ascending urethral infection in acute bacterial prostatitis.急性细菌性前列腺炎中尿道上行感染的分子流行病学证据。
J Urol. 2000 Dec;164(6):1945-7.
4
Cytotoxic necrotizing factor type 1 of uropathogenic Escherichia coli kills cultured human uroepithelial 5637 cells by an apoptotic mechanism.尿路致病性大肠杆菌的1型细胞毒素坏死因子通过凋亡机制杀死培养的人尿道上皮5637细胞。
Infect Immun. 2000 Oct;68(10):5869-80. doi: 10.1128/IAI.68.10.5869-5880.2000.
5
Bacterial dna sequences in prostate tissue from patients with prostate cancer and chronic prostatitis.前列腺癌和慢性前列腺炎患者前列腺组织中的细菌DNA序列。
J Urol. 2000 Oct;164(4):1221-8.
6
Identification of the region of rho involved in substrate recognition by Escherichia coli cytotoxic necrotizing factor 1 (CNF1).鉴定大肠杆菌细胞毒素坏死因子1（CNF1）识别底物时rho蛋白所涉及的区域。
J Biol Chem. 1999 Oct 8;274(41):28999-9004. doi: 10.1074/jbc.274.41.28999.
7
Virulence characteristics of Escherichia coli in acute bacterial prostatitis.急性细菌性前列腺炎中大肠杆菌的毒力特征
J Infect Dis. 1999 Oct;180(4):1378-81. doi: 10.1086/314976.
8
Effect of Escherichia coli cytotoxic necrotizing factor 1 on repair of human bladder cell monolayers in vitro.大肠杆菌细胞毒素坏死因子1对人膀胱细胞单层体外修复的影响。
Infect Immun. 1999 Jul;67(7):3657-61. doi: 10.1128/IAI.67.7.3657-3661.1999.
9
Deamidation of Cdc42 and Rac by Escherichia coli cytotoxic necrotizing factor 1: activation of c-Jun N-terminal kinase in HeLa cells.大肠杆菌细胞毒素坏死因子1对Cdc42和Rac的脱酰胺作用：HeLa细胞中c-Jun氨基末端激酶的激活
Infect Immun. 1999 Feb;67(2):496-503. doi: 10.1128/IAI.67.2.496-503.1999.
10
Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cells.大肠杆菌细胞毒性坏死因子1对Rho GTP酶的激活作用增加了Caco-2细胞的肠道通透性。
Infect Immun. 1998 Nov;66(11):5125-31. doi: 10.1128/IAI.66.11.5125-5131.1998.

1型细胞毒素坏死因子阳性大肠杆菌在大鼠前列腺炎模型中会导致前列腺炎症加剧和组织损伤。

Cytotoxic necrotizing factor type 1-positive Escherichia coli causes increased inflammation and tissue damage to the prostate in a rat prostatitis model.

作者信息

Rippere-Lampe K E, Lang M, Ceri H, Olson M, Lockman H A, O'Brien A D

机构信息

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA.

出版信息

Infect Immun. 2001 Oct;69(10):6515-9. doi: 10.1128/IAI.69.10.6515-6519.2001.

DOI:10.1128/IAI.69.10.6515-6519.2001
PMID:11553597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC98788/
Abstract

Infection of rat prostates with cytotoxic necrotizing factor type 1 (CNF1)-positive uropathogenic Escherichia coli caused more inflammation-mediated morphological and histological tissue damage than did infection with isogenic CNF1-negative mutants. These striking differences occurred despite the finding that bacterial counts for the strain pairs were indistinguishable. We conclude that CNF1 contributes to E. coli virulence in a model of acute prostatitis. To our knowledge, the results of this study provide the first demonstration of a role for any uropathogenic E. coli virulence factor in acute prostatitis.

摘要

用1型细胞毒性坏死因子（CNF1）阳性的尿路致病性大肠杆菌感染大鼠前列腺，比用同基因CNF1阴性突变体感染造成的炎症介导的形态学和组织学组织损伤更多。尽管发现这对菌株的细菌计数没有区别，但仍出现了这些显著差异。我们得出结论，在急性前列腺炎模型中，CNF1有助于大肠杆菌的毒力。据我们所知，本研究结果首次证明了任何尿路致病性大肠杆菌毒力因子在急性前列腺炎中的作用。