志贺毒素1对家兔中枢神经系统的毒性作用。
Toxicity of Shiga toxin 1 in the central nervous system of rabbits.
作者信息
Fujii J, Kinoshita Y, Yutsudo T, Taniguchi H, Obrig T, Yoshida S I
机构信息
Departments of Microbiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
出版信息
Infect Immun. 2001 Oct;69(10):6545-8. doi: 10.1128/IAI.69.10.6545-6548.2001.
Abstract
The action of Shiga toxin (Stx) on the central nervous system was examined in rabbits. Intravenous Stx1 was 44 times more lethal than Stx2 and acted more rapidly than Stx2. However, Stx1 accumulated more slowly in the cerebrospinal fluid than did Stx2. Magnetic resonance imaging demonstrated a predominance of Stx1-dependent lesions in the spinal cord. Pretreatment of the animals with anti-Stx1 antiserum intravenously completely protected against both development of brain lesions and mortality.
摘要
在兔子身上研究了志贺毒素（Stx）对中枢神经系统的作用。静脉注射的Stx1的致死性比Stx2高44倍，且作用比Stx2更快。然而，Stx1在脑脊液中的蓄积比Stx2更慢。磁共振成像显示脊髓中主要是依赖Stx1的病变。给动物静脉注射抗Stx1抗血清进行预处理，可完全预防脑损伤的发生和死亡。
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