志贺毒素1对家兔中枢神经系统的毒性作用。
Toxicity of Shiga toxin 1 in the central nervous system of rabbits.
作者信息
Fujii J, Kinoshita Y, Yutsudo T, Taniguchi H, Obrig T, Yoshida S I
机构信息
Departments of Microbiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
出版信息
Infect Immun. 2001 Oct;69(10):6545-8. doi: 10.1128/IAI.69.10.6545-6548.2001.
Abstract
The action of Shiga toxin (Stx) on the central nervous system was examined in rabbits. Intravenous Stx1 was 44 times more lethal than Stx2 and acted more rapidly than Stx2. However, Stx1 accumulated more slowly in the cerebrospinal fluid than did Stx2. Magnetic resonance imaging demonstrated a predominance of Stx1-dependent lesions in the spinal cord. Pretreatment of the animals with anti-Stx1 antiserum intravenously completely protected against both development of brain lesions and mortality.
摘要
在兔子身上研究了志贺毒素（Stx）对中枢神经系统的作用。静脉注射的Stx1的致死性比Stx2高44倍，且作用比Stx2更快。然而，Stx1在脑脊液中的蓄积比Stx2更慢。磁共振成像显示脊髓中主要是依赖Stx1的病变。给动物静脉注射抗Stx1抗血清进行预处理，可完全预防脑损伤的发生和死亡。
相似文献
1
Toxicity of Shiga toxin 1 in the central nervous system of rabbits.
Infect Immun. 2001 Oct;69(10):6545-8. doi: 10.1128/IAI.69.10.6545-6548.2001.
2
Development of a hybrid Shiga holotoxoid vaccine to elicit heterologous protection against Shiga toxins types 1 and 2.
Vaccine. 2006 May 8;24(19):4122-9. doi: 10.1016/j.vaccine.2006.02.035. Epub 2006 Mar 3.
3
Genetic toxoids of Shiga toxin types 1 and 2 protect mice against homologous but not heterologous toxin challenge.
Vaccine. 2006 Feb 20;24(8):1142-8. doi: 10.1016/j.vaccine.2005.08.094. Epub 2005 Sep 12.
4
Production and characterization of rabbit polyclonal sera against Shiga toxins Stx1 and Stx2 for detection of Shiga toxin-producing Escherichia coli.
Microbiol Immunol. 2008 Oct;52(10):484-91. doi: 10.1111/j.1348-0421.2008.00068.x.
5
Neurotoxicity of intrathecal Shiga toxin 2 and protection by intrathecal injection of anti-Shiga toxin 2 antiserum in rabbits.
Microb Pathog. 1998 Sep;25(3):139-46. doi: 10.1006/mpat.1998.0220.
6
The presence of free shiga-like toxins in stool specimens of patients with diarrhea during one year study.
Pol J Microbiol. 2005;54(1):69-71.
7
New high-affinity monoclonal antibodies against Shiga toxin 1 facilitate the detection of hybrid Stx1/Stx2 in vivo.
PLoS One. 2014 Jun 10;9(6):e99854. doi: 10.1371/journal.pone.0099854. eCollection 2014.
8
Urinary concentrating defect in rats given Shiga toxin: elevation in urinary AQP2 level associated with polyuria.
Life Sci. 2002 May 31;71(2):171-89. doi: 10.1016/s0024-3205(02)01618-1.
9
Baicalein Inhibits Stx1 and 2 of EHE: Effects of Baicalein on the Cytotoxicity, Production, and Secretion of Shiga Toxins of Enterohaemorrhagic Escherichia coli.
Toxins (Basel). 2019 Aug 29;11(9):505. doi: 10.3390/toxins11090505.
10
Escherichia coli serogroup O107/O117 lipopolysaccharide binds and neutralizes Shiga toxin 2.
J Bacteriol. 2004 Aug;186(16):5506-12. doi: 10.1128/JB.186.16.5506-5512.2004.
引用本文的文献
1
Dynamic changes in Shiga toxin (Stx) 1 transducing phage throughout the evolution of O26:H11 Stx-producing Escherichia coli.
Sci Rep. 2023 Mar 27;13(1):4935. doi: 10.1038/s41598-023-32111-8.
2
A One Health Perspective for Defining and Deciphering Pathogenic Potential in Multiple Hosts.
Comp Med. 2021 Feb 1;71(1):3-45. doi: 10.30802/AALAS-CM-20-000054. Epub 2021 Jan 8.
3
Role of Shiga/Vero toxins in pathogenesis.
Microbiol Spectr. 2014 Jun;2(3). doi: 10.1128/microbiolspec.EHEC-0005-2013.
4
Shiga toxin 1 induces on lipopolysaccharide-treated astrocytes the release of tumor necrosis factor-alpha that alter brain-like endothelium integrity.
PLoS Pathog. 2012;8(3):e1002632. doi: 10.1371/journal.ppat.1002632. Epub 2012 Mar 29.
5
Glycosphingolipid functions.
Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7):a004788. doi: 10.1101/cshperspect.a004788.
6
Mouse model of hemolytic-uremic syndrome caused by endotoxin-free Shiga toxin 2 (Stx2) and protection from lethal outcome by anti-Stx2 antibody.
Infect Immun. 2008 Oct;76(10):4469-78. doi: 10.1128/IAI.00592-08. Epub 2008 Aug 11.
7
Development of an experimental hemolytic uremic syndrome in rats.
Pediatr Nephrol. 2008 Apr;23(4):559-67. doi: 10.1007/s00467-007-0727-4. Epub 2008 Feb 6.
8
Effect of globotriaosyl ceramide fatty acid alpha-hydroxylation on the binding by verotoxin 1 and verotoxin 2.
Neurochem Res. 2002 Aug;27(7-8):807-13. doi: 10.1023/a:1020261125008.
本文引用的文献
1
Massive outbreak of Escherichia coli O157:H7 infection in schoolchildren in Sakai City, Japan, associated with consumption of white radish sprouts.
Am J Epidemiol. 1999 Oct 15;150(8):787-96. doi: 10.1093/oxfordjournals.aje.a010082.
2
Brainstem mechanisms of autonomic dysfunction in encephalopathy-associated Shiga toxin 2 intoxication.
Ann Neurol. 1999 Jun;45(6):716-23.
3
Neurotoxicity of intrathecal Shiga toxin 2 and protection by intrathecal injection of anti-Shiga toxin 2 antiserum in rabbits.
Microb Pathog. 1998 Sep;25(3):139-46. doi: 10.1006/mpat.1998.0220.
4
Effect of antimicrobial agents, especially fosfomycin, on the production and release of Vero toxin by enterohaemorrhagic Escherichia coli O157:H7.
FEMS Immunol Med Microbiol. 1997 Sep;19(1):57-64. doi: 10.1111/j.1574-695X.1997.tb01072.x.
5
Magnetic resonance imaging and histopathological study of brain lesions in rabbits given intravenous verotoxin 2.
Infect Immun. 1996 Dec;64(12):5053-60. doi: 10.1128/iai.64.12.5053-5060.1996.
6
Neuronal and vascular pathology produced by verocytotoxin 2 in the rabbit central nervous system.
Acta Neuropathol. 1996;91(3):254-62. doi: 10.1007/s004010050423.
7
Vero cytotoxin-producing Escherichia coli, particularly serogroup O 157, associated with human infections in the United Kingdom: 1989-91.
Epidemiol Infect. 1993 Jun;110(3):591-600. doi: 10.1017/s0950268800051013.
8
Direct evidence of neuron impairment by oral infection with verotoxin-producing Escherichia coli O157:H- in mitomycin-treated mice.
Infect Immun. 1994 Aug;62(8):3447-53. doi: 10.1128/iai.62.8.3447-3453.1994.
9
The importance of nonrenal involvement in hemolytic-uremic syndrome.
Pediatrics. 1980 Jan;65(1):115-20.
10
Hemorrhagic colitis associated with a rare Escherichia coli serotype.
N Engl J Med. 1983 Mar 24;308(12):681-5. doi: 10.1056/NEJM198303243081203.
Zotero 插件