一种新型γ-氨基丁酸能物质加巴利德对猫脑生物电活动的影响。

Effect of a new GABA-ergic substance gabalid on brain bioelectric activity of cat.

作者信息

Yossifov T, Varonos D, Papadopolu Z, Bantoutova I, Ovtcharov R

出版信息

Acta Physiol Pharmacol Bulg. 1983;9(4):48-53.

Abstract

The effect of the GABA-ergic substance gabalid on the bioelectric activity of cats was studied using electrodes introduced into substantia nigra (SN), nucleus caudatus (NC), Amygdala basolateralis ( Abl ), mesencephalic reticular formation (MRF) and sensor motor cortex (Sm). Gabalid was administered i.p. in doses of 100 to 200 mg/k increased amplitude and frequency of spontaneous and evoked EEG activity in NC. Suppression of mean amplitude, driving reaction and evoked potentials was observed in Abl . Most expressive were the changes in the ECoG activity. We observed many regularly appearing bursts of high-amplitude alow "spindles" and an increase in the number of medium and high-amplitude waves.

摘要

使用插入到黑质（SN）、尾状核（NC）、基底外侧杏仁核（Abl）、中脑网状结构（MRF）和感觉运动皮层（Sm）的电极，研究了γ-氨基丁酸能物质加巴立对猫生物电活动的影响。加巴立以100至200mg/kg的剂量腹腔注射，可增加NC中自发和诱发脑电图活动的幅度和频率。在Abl中观察到平均幅度、驱动反应和诱发电位受到抑制。最明显的是大脑皮层电图活动的变化。我们观察到许多规则出现的高幅度低频“纺锤波”爆发以及中高幅度波数量增加。