Effect of a new GABA-ergic substance gabalid on brain bioelectric activity of cat.

The effect of the GABA-ergic substance gabalid on the bioelectric activity of cats was studied using electrodes introduced into substantia nigra (SN), nucleus caudatus (NC), Amygdala basolateralis ( Abl ), mesencephalic reticular formation (MRF) and sensor motor cortex (Sm). Gabalid was administered i.p. in doses of 100 to 200 mg/k increased amplitude and frequency of spontaneous and evoked EEG activity in NC. Suppression of mean amplitude, driving reaction and evoked potentials was observed in Abl . Most expressive were the changes in the ECoG activity. We observed many regularly appearing bursts of high-amplitude alow "spindles" and an increase in the number of medium and high-amplitude waves.