Elci O C, Dosemeci M, Blair A
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852-7240, United States.
Scand J Work Environ Health. 2001 Aug;27(4):233-9. doi: 10.5271/sjweh.610.
A hospital-based case-referent study was conducted in Turkey to provide further information on occupational risk factors and laryngeal cancer.
Among 7631 cancer cases seen at an oncology treatment center between 1979 and 1984, 958 laryngeal cancer cases were identified among men. Occupational history, tobacco and alcohol use, and demographic data were obtained from patients with a standardized questionnaire. Special 7-digit standard occupational and industrial codes were created to classify the job and industrial titles of the subjects. After exclusions, 940 laryngeal cancer cases and 1519 referents were available for study. Age-, smoking- and alcohol-adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were calculated.
Excess laryngeal cancer occurred among guards (OR 1.5, 95% CI 1.1-2.1), production supervisors (OR 1.8, 95% CI 1.1-3.1), textile workers (OR 1.9, 95% CI 1.2-3.3), drivers (OR 1.7, 95% CI 1.1-2.4), construction workers (OR 1.7, 95% Cl 1.2-2.6), and workers in grain mills (OR 3.1, 95% CI: 1.3-7.6), trade unions (OR 3.6, 95% CI: 1.1-11.7) and local government services (OR 4.7, 95% CI 1.7-12.5). Supraglottic cancer was excessive among the textile workers, construction workers, and local government laborers, all with potential dust exposure. The risks of the general managers, electricians, and workers from industries such as pharmaceutical production, industrial machinery production, electric utilities, and retail services were lower than expected.
The risk of laryngeal cancer was associated with several occupations, and supraglottic larynx cancer appears to be more common among workers in dusty occupations and industries.
在土耳其开展了一项基于医院的病例对照研究，以获取有关职业危险因素与喉癌的更多信息。
在1979年至1984年间肿瘤治疗中心诊治的7631例癌症病例中，确诊958例男性喉癌病例。通过标准化问卷从患者处获取职业史、烟草和酒精使用情况以及人口统计学数据。创建了特殊的7位标准职业和行业代码，用于对研究对象的工作和行业头衔进行分类。排除部分病例后，940例喉癌病例和1519例对照可供研究。计算了年龄、吸烟和饮酒调整后的优势比（OR）及95%置信区间（95%CI）。
警卫（OR 1.5，95%CI 1.1 - 2.1）、生产主管（OR 1.8，95%CI 1.1 - 3.1）、纺织工人（OR 1.9，95%CI 1.2 - 3.3）、司机（OR 1.7，95%CI 1.1 - 2.4）、建筑工人（OR 1.7，95%Cl 1.2 - 2.6）、谷物加工厂工人（OR 3.1，95%CI：1.3 - 7.6）、工会成员（OR 3.6，95%CI：1.1 - 11.7）和地方政府服务人员（OR 4.7，95%CI 1.7 - 12.5）患喉癌风险增加。声门上癌在纺织工人、建筑工人和地方政府劳动者中高发，这些职业均可能接触粉尘。总经理、电工以及制药生产、工业机械生产、电力公用事业和零售服务等行业工人的风险低于预期。
喉癌风险与多种职业相关，声门上喉癌在接触粉尘的职业和行业工人中似乎更为常见。
