Elci Omur Cinar, Akpinar-Elci Muge, Blair Aaron, Dosemeci Mustafa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
J Occup Environ Med. 2003 Oct;45(10):1100-6. doi: 10.1097/01.jom.0000085890.50021.6f.
Laryngeal cancer is the second most common cancer among men in Turkey. In this hospital based case-control study, we evaluated laryngeal cancer risks from occupational chemical exposures. We analyzed 940 laryngeal cancer cases and 1519 controls. Occupational history, tobacco, and alcohol use and demographic information were obtained by a questionnaire. The job and industries were classified by special seven-digit codes. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) based on a developed exposure matrix for chemicals, including diesel exhaust, gasoline exhaust, polycyclic aromatic hydrocarbons (PAHs), formaldehyde, and solvents. An excess of laryngeal cancer occurred with diesel exhaust (OR=1.5, 95% CI=1.3-1.9), gasoline exhaust (OR=1.6, 95% CI=1.3-2.0), and PAHs (OR=1.3, 95% CI=1.1-1.6). There was a dose-response relationship for these substances with supraglottic cancers (P<0.000). The PAH association only occurred among those who also had exposure to diesel exhaust.
喉癌是土耳其男性中第二常见的癌症。在这项基于医院的病例对照研究中，我们评估了职业化学物质暴露导致喉癌的风险。我们分析了940例喉癌病例和1519名对照。通过问卷调查获取职业史、烟草和酒精使用情况以及人口统计学信息。工作和行业通过特殊的七位代码进行分类。我们根据一个针对包括柴油废气、汽油废气、多环芳烃（PAHs）、甲醛和溶剂在内的化学物质编制的暴露矩阵计算比值比（OR）和95%置信区间（CI）。柴油废气（OR = 1.5，95% CI = 1.3 - 1.9）、汽油废气（OR = 1.6，95% CI = 1.3 - 2.0）和多环芳烃（OR = 1.3，95% CI = 1.1 - 1.6）与喉癌发病增加有关。这些物质与声门上癌存在剂量反应关系（P < 0.000）。多环芳烃的关联仅发生在那些同时暴露于柴油废气的人群中。
