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That impish TIMP: the tissue inhibitor of metalloproteinases-3.

作者信息

Woessner J F

机构信息

Department of Biochemistry R-127, University of Miami School of Medicine, PO Box 016960, Miami, Florida 33101, USA.

出版信息

J Clin Invest. 2001 Sep;108(6):799-800. doi: 10.1172/JCI13709.

DOI:10.1172/JCI13709
PMID:11560946
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC200938/
Abstract
摘要

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That impish TIMP: the tissue inhibitor of metalloproteinases-3.那个顽皮的TIMP：金属蛋白酶组织抑制剂-3。
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[Expression of matrix metalloproteinases-9,2,7,and tissue inhibitor of metalloproteinases-1,2,3 mRNA in ovarian tumors and their clinical significance].[基质金属蛋白酶-9、2、7及金属蛋白酶组织抑制剂-1、2、3 mRNA在卵巢肿瘤中的表达及其临床意义]
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Changes in the balance of the tissue inhibitor of matrix metalloproteinases (TIMPs)-1 and -3 may promote keratocyte apoptosis in keratoconus.基质金属蛋白酶组织抑制剂（TIMPs）-1和-3平衡的改变可能会促进圆锥角膜中角膜细胞的凋亡。
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Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane.突变型纤维连接蛋白-3导致蛋白聚糖积聚并损害其穿过布鲁赫膜的扩散。
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Plasma levels of the tissue inhibitor matrix metalloproteinase-3 as a potential biomarker in oral cancer progression.作为口腔癌进展潜在生物标志物的基质金属蛋白酶组织抑制剂-3的血浆水平
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Polymorphisms and Plasma Levels of Tissue Inhibitor of Metalloproteinase-3: Impact on Genetic Susceptibility and Clinical Outcome of Oral Cancer.基质金属蛋白酶-3组织抑制剂的多态性与血浆水平：对口腔癌遗传易感性和临床结局的影响
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TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence.TIMP3 通过不同的 TNF 依赖性调节乳腺上皮细胞凋亡和免疫细胞募集。
PLoS One. 2011;6(10):e26718. doi: 10.1371/journal.pone.0026718. Epub 2011 Oct 28.
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Fetal hypoxia and programming of matrix metalloproteinases.胎儿缺氧与基质金属蛋白酶的程序化。
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Podocytes require the engagement of cell surface heparan sulfate proteoglycans for adhesion to extracellular matrices.足细胞需要细胞表面的硫酸乙酰肝素蛋白聚糖的参与，才能黏附于细胞外基质。
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本文引用的文献

1
Accelerated apoptosis in the Timp-3-deficient mammary gland.Timp-3基因缺陷型乳腺中细胞凋亡加速。
J Clin Invest. 2001 Sep;108(6):831-41. doi: 10.1172/JCI13171.
2
Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3).缺乏金属蛋白酶组织抑制剂-3（TIMP-3）的小鼠肺部出现自发性气腔扩大。
J Clin Invest. 2001 Sep;108(6):817-29. doi: 10.1172/JCI12067.
3
TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5).组织金属蛋白酶抑制因子-3是聚集蛋白聚糖酶1（含血小板反应蛋白基序的解聚素样金属蛋白酶-4）和聚集蛋白聚糖酶2（含血小板反应蛋白基序的解聚素样金属蛋白酶-5）的强效抑制剂。
J Biol Chem. 2001 Apr 20;276(16):12501-4. doi: 10.1074/jbc.C000848200. Epub 2001 Jan 23.
4
ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3.解整合素样金属蛋白酶12-S（ADAM 12-S）可裂解胰岛素样生长因子结合蛋白-3（IGFBP-3）和胰岛素样生长因子结合蛋白-5（IGFBP-5），并受金属蛋白酶组织抑制因子-3（TIMP-3）的抑制。
Biochem Biophys Res Commun. 2000 Nov 30;278(3):511-5. doi: 10.1006/bbrc.2000.3835.
5
Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus. Metalloproteinase inhibition is associated with proapoptotic activity.金属蛋白酶组织抑制剂-3死亡结构域定位于N端。金属蛋白酶抑制与促凋亡活性相关。
J Biol Chem. 2000 Dec 29;275(52):41358-63. doi: 10.1074/jbc.M007929200.
6
Cell surface heparan sulfate proteoglycans: selective regulators of ligand-receptor encounters.细胞表面硫酸乙酰肝素蛋白聚糖：配体-受体相互作用的选择性调节因子。
J Biol Chem. 2000 Sep 29;275(39):29923-6. doi: 10.1074/jbc.R000008200.
7
TIMP-3 binds to sulfated glycosaminoglycans of the extracellular matrix.基质金属蛋白酶组织抑制因子-3与细胞外基质的硫酸化糖胺聚糖结合。
J Biol Chem. 2000 Oct 6;275(40):31226-32. doi: 10.1074/jbc.M000907200.
8
The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3.组织金属蛋白酶抑制剂-1（TIMP-1）和组织金属蛋白酶抑制剂-3（TIMP-3）可抑制解聚素和金属蛋白酶10（ADAM-10）的体外活性。
FEBS Lett. 2000 May 19;473(3):275-9. doi: 10.1016/s0014-5793(00)01528-3.
9
Tissue inhibitors of metalloproteinases: evolution, structure and function.金属蛋白酶组织抑制剂：进化、结构与功能
Biochim Biophys Acta. 2000 Mar 7;1477(1-2):267-83. doi: 10.1016/s0167-4838(99)00279-4.
10
Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase.Syndecan-1和-4胞外结构域的脱落受多种信号通路调控，并由一种对TIMP-3敏感的金属蛋白酶介导。
J Cell Biol. 2000 Feb 21;148(4):811-24. doi: 10.1083/jcb.148.4.811.