绵羊和兔关节软骨体外合成透明质酸。
The synthesis of hyaluronic acid by sheep and rabbit articular cartilage in vitro.
作者信息
Gillard G C, Caterson B, Lowther D A
出版信息
Biochem J. 1975 Feb;145(2):209-13. doi: 10.1042/bj1450209.
Abstract
Standard methods of glycosaminoglycan separation were used to confirm the presence of hyaluronic acid in sheep and rabbit articular cartilage. During incubation of carilage in vitro in the presence of [1-14 C]acetate, cartilage cells synthesize this macromolecule and, under the conditions used, it appears to have a shorter turnover time than chondroitin suplhate in the same tissue. The possible functions of hyaluronic acid in cartilage are discussed.
摘要
采用糖胺聚糖分离的标准方法来确认绵羊和兔关节软骨中透明质酸的存在。在含有[1-¹⁴C]乙酸盐的情况下对软骨进行体外培养时，软骨细胞会合成这种大分子，并且在所使用的条件下，它在同一组织中的周转时间似乎比硫酸软骨素短。文中讨论了透明质酸在软骨中的可能功能。
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