低风险白种人群中胆管癌的危险因素
Risk factors for cholangiocarcinoma in a low risk Caucasian population.
作者信息
Kuper H, Lagiou P, Mucci L A, Tamimi R, Benetou V, Trichopoulos D
机构信息
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
出版信息
Soz Praventivmed. 2001;46(3):182-5. doi: 10.1007/BF01324254.
OBJECTIVES
Little is known about the etiology of cholangiocarcinoma, apart from its association with liver fluke infestation.
METHODS
A case-control study was conducted in Athens and included six cholangiocarcinoma cases, 333 hepatocellular carcinoma cases and 360 controls with minor ailments or injuries. All subjects were interviewed and tested for hepatitis B and C infection. For all six cholangiocarcinomas, 97 hepatocellular carcinomas and 129 controls, sex steroids were determined in the blood.
RESULTS
Hepatitis B or C viruses, tobacco smoking, alcohol drinking and diabetes mellitus were not related to cholangiocarcinoma, but history of thyroid disease was. Estradiol levels were higher among cholangiocarcinoma cases than among the other two groups.
CONCLUSIONS
This study provides evidence that endocrine and autoimmune factors are important in the etiology of cholangiocarcinoma.
目的
除了与肝吸虫感染有关外，人们对胆管癌的病因知之甚少。
方法
在雅典进行了一项病例对照研究，纳入了6例胆管癌病例、333例肝细胞癌病例和360例患有轻微疾病或受伤的对照者。对所有受试者进行了访谈，并检测了乙型和丙型肝炎感染情况。对6例胆管癌、97例肝细胞癌和129例对照者的血液中的性类固醇进行了测定。
结果
乙型或丙型肝炎病毒、吸烟、饮酒和糖尿病与胆管癌无关，但甲状腺疾病史与之有关。胆管癌病例中的雌二醇水平高于其他两组。
结论
本研究提供了证据表明内分泌和自身免疫因素在胆管癌病因中很重要。
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