Robibaro B, Hoppe H C, Yang M, Coppens I, Ngô H M, Stedman T T, Paprotka K, Joiner K A
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, LCI, 808333 Cedar Street, New Haven, CT 06520-8022, USA.
Int J Parasitol. 2001 Oct;31(12):1343-53. doi: 10.1016/s0020-7519(01)00252-1.
A fundamental property of any eukaryotic cell is endocytosis, that is the ability to take up external fluid, solutes and particulate matter into membrane-bound intracellular vesicles by various mechanisms. Toxoplasma gondii is an intracellular protozoan parasite of the phylum Apicomplexa with a wide geographical and host range distribution. Significant progress in studying the cell biology of this parasite has been accomplished over the last few years. Only recently endocytic compartments and endocytic trafficking have come to a closer dissection in T. gondii. In this review, we discuss the evidence for an endocytic compartment and present a model for an endocytic pathway in Toxoplasma against a background of endocytosis in kinetoplastida and the extensive insights gained from mammalian and yeast cells.
任何真核细胞的一个基本特性是内吞作用，即通过各种机制将细胞外液体、溶质和颗粒物摄取到膜结合的细胞内囊泡中的能力。刚地弓形虫是顶复门的一种细胞内原生动物寄生虫，具有广泛的地理分布和宿主范围。在过去几年中，对这种寄生虫细胞生物学的研究取得了重大进展。直到最近，才对刚地弓形虫的内吞区室和内吞运输进行了更深入的剖析。在这篇综述中，我们讨论了内吞区室的证据，并在动质体的内吞作用以及从哺乳动物和酵母细胞中获得的广泛见解的背景下，提出了一个刚地弓形虫内吞途径的模型。
