红辣椒（Capsicum annuum L.）果实中类胡萝卜素的癌症化学预防活性

Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L.

作者信息

Maoka T, Mochida K, Kozuka M, Ito Y, Fujiwara Y, Hashimoto K, Enjo F, Ogata M, Nobukuni Y, Tokuda H, Nishino H

机构信息

Research Institute for Production Development, 15 Shimogamo-Morimoto-cho, Sakyo-ku, 606-0805, Kyoto, Japan.

出版信息

Cancer Lett. 2001 Oct 30;172(2):103-9. doi: 10.1016/s0304-3835(01)00635-8.

DOI:10.1016/s0304-3835(01)00635-8

PMID:11566483

Abstract

Capsanthin and related carotenoids isolated from the fruits of red paprika Capsicum annuum L. showed potent in vitro anti-tumor-promoting activity with inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among them, capsanthin diester and capsorbin diester showed strong inhibitory effects. Furthermore, capsanthin , capsanthin 3'-ester and capsanthin 3,3'-diester , major carotenoids in paprika, exhibited potent anti-tumor-promoting activity in an in vivo mouse skin two-stage carcinogenesis assay using 7, 12-dimethylbenz[a]anthracene as an initiator and TPA as a promoter.

摘要

从红辣椒（辣椒属）果实中分离出的辣椒红素及相关类胡萝卜素在体外显示出强大的抗肿瘤促进活性，对肿瘤促进剂12-O-十四烷酰佛波醇-13-乙酸酯（TPA）诱导的爱泼斯坦-巴尔病毒早期抗原（EBV-EA）激活具有抑制作用。其中，辣椒红素二酯和辣椒玉红素二酯显示出强烈的抑制作用。此外，辣椒红素、辣椒红素3'-酯和辣椒红素3,3'-二酯（辣椒中的主要类胡萝卜素）在以7,12-二甲基苯并[a]蒽为引发剂、TPA为促进剂的体内小鼠皮肤两阶段致癌试验中表现出强大的抗肿瘤促进活性。