Zanetta R A, Amaku M, Azevedo R S, Zanetta D M, Burattini M N, Massad E
Faculdade de Medicina da Universidade de São Paulo and LIM-01 HCFMUSP, São Paulo, Brazil.
Vaccine. 2001 Oct 12;20(1-2):226-34. doi: 10.1016/s0264-410x(01)00267-5.
In order to investigate if the changing levels of measles antibody in women resulting from extensive vaccination programs influence the susceptibility of children, we measured the seroprevalence of measles virus antibody of children in the first year of life and of their mothers. We compared maternal antibody decay of two groups of children: those whose mothers were 25 years old or more (mothers born in the pre-vaccination era), and less than 25 years old (mothers born in the vaccination era). Therefore, the 25-year-age cut-off was chosen to distinguish between vaccinated and non-vaccinated mothers. We also compared the immunogenicity of measles vaccine in children from 6 to 12 months of age, in these two groups and also according to their mother's serostatus. The optimal age of vaccination for a routine program was estimated by means of mathematical models. This study was carried out in a sample of 1216 mothers and their respective children. Our results indicate that the optimal age for vaccination of the whole sample was 15 months, 17 months for children born from older mothers, 14 months for children born from younger mothers, 17 months for children born from seropositive mothers and 12 months for children born from seronegative mothers. Therefore, a change to an earlier age of routine vaccination is not justified by our results.
为了调查广泛的疫苗接种计划导致的女性麻疹抗体水平变化是否会影响儿童的易感性，我们测量了一岁儿童及其母亲的麻疹病毒抗体血清阳性率。我们比较了两组儿童的母亲抗体衰减情况：母亲年龄在25岁及以上的儿童（出生于疫苗接种前时代的母亲）和年龄小于25岁的儿童（出生于疫苗接种时代的母亲）。因此，选择25岁作为区分接种疫苗和未接种疫苗母亲的年龄界限。我们还比较了这两组6至12个月大儿童以及根据其母亲血清状态的麻疹疫苗免疫原性。通过数学模型估计常规计划的最佳接种年龄。本研究在1216名母亲及其各自孩子的样本中进行。我们的结果表明，整个样本的最佳接种年龄为15个月，年龄较大母亲所生孩子为17个月，年龄较小母亲所生孩子为14个月，血清阳性母亲所生孩子为17个月，血清阴性母亲所生孩子为12个月。因此，我们的结果表明没有理由将常规接种年龄提前。
