El Hendy H A, Yousef M I, Abo El-Naga N I
Department of Home Economics, Faculty of Agriculture, El-Shatby, Alexandria University, Alexandria, Egypt.
Toxicology. 2001 Oct 15;167(2):163-70. doi: 10.1016/s0300-483x(01)00373-0.
Zinc has a wide spectrum of biological activities and its deficiency has been related to various dysfunctions and alterations of normal cell metabolism. The effects of adequate Zn level (38 mg/kg diet, control) and two low levels that create Zn deficiencies (19 mg/kg diet, 1/2 of control and 3.8 mg/kg diet, 1/10 of control) were investigated in growing male and female rats for 10 weeks. This allowed for evaluation of the effects these Zn levels may have on body weight gain, specific organ weights, blood parameters, and serum concentrations of Zn, Cu and Fe. Rats fed Zn-deficient diets gained less (P<0.05) than the control groups. There was increase (P<0.05) in liver and spleen weights, and a decrease (P<0.05) in testes weight. However, brain, kidney, heart, and lung weights were not affected (P<0.05). Hematological parameters that were decreased (P<0.05) by Zn deficiency included hemoglobin (Hb), total erythrocyte count (TEC) and packed cell volume (PCV) with the magnitude being dose-dependent. Serum concentrations of total protein, globulin, glucose, and high density lipoprotein (HDL) also decreased (P<0.05) in a dose-dependent manner. Zn deficiency increased (P<0.05) total leukocyte count (TLC) and concentrations of serum albumin, total lipids, cholesterol, triglycerides and low density lipoprotein (LDL) in a dose-dependent manner. Serum concentrations of urea and creatinine were, however, not affected (P<0.05) by zinc deficiency. Zn-deficient rats had lower serum concentrations of Zn, Cu and Fe. These results showed that Zn deficiency has negative effects on growth rate, specific organ weights, hematological parameters, and serum levels of Zn, Cu and Fe, especially in rats fed the lowest Zn level.
锌具有广泛的生物活性，其缺乏与正常细胞代谢的各种功能障碍和改变有关。研究了适宜锌水平（38毫克/千克日粮，对照组）和两种造成锌缺乏的低水平（19毫克/千克日粮，对照组的1/2；3.8毫克/千克日粮，对照组的1/10）对生长中的雄性和雌性大鼠10周的影响。这使得能够评估这些锌水平可能对体重增加、特定器官重量、血液参数以及锌、铜和铁的血清浓度产生的影响。喂食缺锌日粮的大鼠体重增加比对照组少（P<0.05）。肝脏和脾脏重量增加（P<0.05），睾丸重量减少（P<0.05）。然而，脑、肾、心和肺的重量未受影响（P<0.05）。锌缺乏导致降低（P<0.05）的血液学参数包括血红蛋白（Hb）、总红细胞计数（TEC）和红细胞压积（PCV），其降低幅度呈剂量依赖性。血清总蛋白、球蛋白、葡萄糖和高密度脂蛋白（HDL）的浓度也呈剂量依赖性降低（P<0.05）。锌缺乏以剂量依赖性方式增加（P<0.05）总白细胞计数（TLC）以及血清白蛋白、总脂质、胆固醇甘油三酯和低密度脂蛋白（LDL）的浓度。然而，血清尿素和肌酐的浓度不受锌缺乏的影响（P<0.05）。缺锌大鼠的血清锌、铜和铁浓度较低。这些结果表明，锌缺乏对生长速率、特定器官重量、血液学参数以及锌、铜和铁的血清水平有负面影响，尤其是在喂食最低锌水平日粮的大鼠中。
