Kraegen E W, Lazarus L, Meler H, Campbell L, Chia Y O
Br Med J. 1975 Aug 23;3(5981):464-6. doi: 10.1136/bmj.3.5981.464.
In the use of low-level intravenous insulin infusion for treating diabetic hyperglycaemia and ketoacidosis adsorption of insulin to containers or plastic infusion apparatus results in significant losses of 60-80% of insulin in dilute physiological saline solution (40 U/l). It is therefore necessary to add protein to the carrier solution to minimize losses and maintain a constant delivery rate. Recovery studies showed that 3.5% w/v polygeline solution (polymer of degraded gelatin) was a suitable medium for this purpose, offering some advantages over human serum albumin. A minimum concentration of 0.5% polygeline was required to ensure adequate delivery of insulin to the patient.
在使用低剂量静脉胰岛素输注治疗糖尿病高血糖症和酮症酸中毒时，胰岛素会吸附在容器或塑料输注装置上，导致在稀生理盐溶液（40 U/l）中60 - 80%的胰岛素显著损失。因此，有必要在载体溶液中添加蛋白质，以尽量减少损失并维持恒定的输注速率。回收率研究表明，3.5% w/v的聚明胶肽溶液（降解明胶聚合物）是实现此目的的合适介质，比人血清白蛋白具有一些优势。需要至少0.5%的聚明胶肽浓度，以确保向患者充分输送胰岛素。
