Kidson W, Casey J, Kraegen E, Lazarus L
Br Med J. 1974 Jun 29;2(5921):691-4. doi: 10.1136/bmj.2.5921.691.
A new and simple form of insulin therapy for diabetic hyperglycaemia and ketoacidosis has been developed using a continuous intravenous infusion of insulin at a rate of 2.4 U/hr to maintain serum insulin concentration at physiological levels. This rate raises the mean serum insulin to 83 muU/ml and has a therapeutic effect which is not augmented by higher infusion rates. The response to such low doses of insulin indicates a need for a reappraisal of currently held theories about insulin resistance in diabetic ketoacidosis. In 11 diabetic patients with a mean plasma glucose of 514 mg/100 ml this therapy produced continuous falls in plasma glucose at a mean rate of 75 mg/100 ml/hr, and 10 out of 11 patients recovered within eight hours. This form of therapy is simple to institute, not complicated by hypoglycaemia, and avoids the confusion and empiricism of previously described forms of therapy.
一种用于治疗糖尿病高血糖和酮症酸中毒的新型简易胰岛素疗法已被研发出来，该疗法通过以每小时2.4单位的速率持续静脉输注胰岛素，将血清胰岛素浓度维持在生理水平。这个速率可使平均血清胰岛素升高至83微单位/毫升，且具有治疗效果，更高的输注速率并不会增强这种效果。对如此低剂量胰岛素的反应表明，有必要重新评估目前关于糖尿病酮症酸中毒中胰岛素抵抗的理论。在11名平均血浆葡萄糖水平为514毫克/100毫升的糖尿病患者中，这种疗法使血浆葡萄糖以平均每小时75毫克/100毫升的速率持续下降，11名患者中有10名在8小时内康复。这种治疗形式易于实施，不会因低血糖而复杂化，并且避免了先前描述的治疗形式的混乱和经验性。
