Bowers D, McKenzie D, Dutta D, Wheeless C R, Cohen W R
Department of Obstetrics and Gynecology, and the Institute for Special Pelvic Surgery, Sinai Hospital of Baltimore, MD, USA.
Am J Obstet Gynecol. 2001 Sep;185(3):614-7. doi: 10.1067/mob.2001.117185.
We sought to determine whether postcesarean treatment of rats with growth hormone (GH) affected the strength of the uterine incision in the puerperium and in a subsequent pregnancy.
Forty-eight near-term pregnant rats were delivered by cesarean section. Half received subcutaneous recombinant human GH (2.0 mg x kg(-1) x d(-1)) for 7 days; control animals received saline injections. Four weeks after delivery, the uterine bursting pressure was determined in 5 treated and 5 control animals. Eight rats in each group were used to study uterine hydroxyproline concentrations and the histologic characteristics of the scar. Twenty-two animals were rebred 30 to 40 days after their cesarean sections. After repeat cesarean delivery, on day 19, the bursting pressure and hydroxyproline concentrations of the previous hysterotomy scar were determined.
The uterine horn bursting pressure in the GH-treated animals was significantly greater than that in the control animals both 28 days postpartum and near term in a subsequent pregnancy. The uterine hydroxyproline concentrations followed the same pattern. Histologic study of the scars showed they were thicker and had less cellularity in the treated animals than in the control animals.
Postcesarean treatment with GH increased the bursting strength of rat uterine incisions. This effect was accompanied by a significant increase in collagen content and persisted through a subsequent pregnancy.
我们试图确定剖宫产术后用生长激素（GH）治疗大鼠是否会影响产褥期及随后妊娠时子宫切口的强度。
48只近足月妊娠大鼠行剖宫产分娩。一半大鼠皮下注射重组人生长激素（2.0mg·kg⁻¹·d⁻¹），共7天；对照动物注射生理盐水。分娩后4周，测定5只治疗组和5只对照组动物的子宫破裂压力。每组8只大鼠用于研究子宫羟脯氨酸浓度和瘢痕的组织学特征。22只动物在剖宫产术后30至40天再次受孕。再次剖宫产分娩后，于第19天测定先前子宫切开术瘢痕的破裂压力和羟脯氨酸浓度。
GH治疗组动物的子宫角破裂压力在产后28天及随后妊娠接近足月时均显著高于对照组动物。子宫羟脯氨酸浓度呈现相同模式。瘢痕的组织学研究表明，与对照组动物相比，治疗组动物的瘢痕更厚且细胞成分更少。
剖宫产术后用GH治疗可增加大鼠子宫切口的破裂强度。这种作用伴随着胶原蛋白含量的显著增加，并持续至随后的妊娠。
