Department of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Beijing, People's Republic of China.
Br J Nutr. 2010 Dec;104(11):1621-7. doi: 10.1017/S0007114510002692. Epub 2010 Aug 9.
We sought to determine whether postcaesarean treatment with whey peptides (WP) affects the healing of skin and uterine incision in rats during puerperium. Forty-eight rats were randomly divided into two groups. After a caesarean section, twenty-four rats were intragastrically administered WP, while others were administered a control vehicle. On days 7, 14 and 21 after delivery, the serum total protein/albumin concentration, skin tensile strength, uterine bursting pressure, skin/uterine hydroxyproline (Hyp) concentration and histological characteristics of the scar were measured in eight rats in each group. In the WP group, the albumin concentration, skin tensile strength, uterine bursting pressure and Hyp concentration in the skin increased significantly on days 21, 7, 14 and 21, respectively. Low neutrophil count and smaller scar width in the skin incision were found in the WP group on day 7. Postcaesarean treatment with WP promoted significant wound healing in the skin incision, and had a significant wound healing potential in the uterus.
我们旨在探究产后给予乳清肽（WP）治疗是否会影响产后大鼠皮肤和子宫切口的愈合。48 只大鼠被随机分为两组。行剖宫产术后，24 只大鼠给予 WP 灌胃，而其他大鼠给予对照载体。分娩后第 7、14 和 21 天，每组 8 只大鼠测量血清总蛋白/白蛋白浓度、皮肤拉伸强度、子宫破裂压、皮肤/子宫羟脯氨酸（Hyp）浓度和瘢痕的组织学特征。在 WP 组中，白蛋白浓度、皮肤拉伸强度、子宫破裂压和 Hyp 浓度分别于第 21、7、14 和 21 天显著增加。第 7 天 WP 组皮肤切口处的中性粒细胞计数较低，瘢痕宽度较小。产后给予 WP 治疗可显著促进皮肤切口的愈合，对子宫也有显著的愈合潜力。
