Ciprandi G, Tosca M, Passalacqua G, Canonica G W
Allergy and Immunology Clinic, Genoa, Italy.
Ann Allergy Asthma Immunol. 2001 Sep;87(3):222-6. doi: 10.1016/S1081-1206(10)62230-2.
Experimental data demonstrate that mite allergy is characterized by persistent chronic inflammation, even during asymptomatic periods. This suggests that long-term continuous treatment be included in the global strategy of allergy treatment.
We conducted a study to evaluate whether regularly administered cetirizine reduces allergic symptoms and drug prescriptions in children with mite allergy.
In this double-blind, randomized, placebo-controlled study, two parallel groups of 10 children with mite allergy (mean age: 6.5 years) received either cetirizine or placebo daily for 6 months. Participants were allowed to take rescue medications for rhinitis and/or mild asthma. The symptoms (nasal itching, sneezing, obstruction, rhinorrhea, conjunctival itching, lacrimation, conjunctival hyperemia, cough, wheezing, and chest tightness) were recorded on a diary card. The intake of cetirizine (as additional symptomatic treatment), antibiotics, acetaminophen, beta2-agonists, inhaled and systemic corticosteroids was also recorded.
Symptom scores and drug consumption were significantly lower (P < 0.05) in the cetrizine-treated group versus the placebo group. The greatest reductions were in cetirizine itself, inhaled corticosteroids, beta2-agonists, and antibiotics. No side effects were reported in either group.
In mite-allergic children, cetirizine administered daily for prolonged periods decreases symptoms of and drug prescriptions for allergic rhinitis and asthma compared with symptomatic treatment.
实验数据表明，即使在无症状期，螨过敏也以持续性慢性炎症为特征。这表明长期持续治疗应纳入全球过敏治疗策略。
我们开展了一项研究，以评估定期服用西替利嗪是否能减轻螨过敏儿童的过敏症状并减少药物处方。
在这项双盲、随机、安慰剂对照研究中，两组平行的10名螨过敏儿童（平均年龄：6.5岁）每天分别服用西替利嗪或安慰剂，持续6个月。参与者可服用治疗鼻炎和/或轻度哮喘的急救药物。症状（鼻痒、打喷嚏、鼻塞、流涕、结膜瘙痒、流泪、结膜充血、咳嗽、喘息和胸闷）记录在日记卡上。还记录了西替利嗪（作为额外的对症治疗）、抗生素、对乙酰氨基酚、β2激动剂、吸入性和全身性皮质类固醇的摄入量。
与安慰剂组相比，西替利嗪治疗组的症状评分和药物消耗量显著更低（P < 0.０5）。减少最多的是西替利嗪本身、吸入性皮质类固醇、β2激动剂和抗生素。两组均未报告副作用。
在螨过敏儿童中，与对症治疗相比，长期每日服用西替利嗪可减轻过敏性鼻炎和哮喘的症状并减少药物处方。
