Davis R, Feldhaus J, Heveran J, Wicks R, Peckham M
Clin Chem. 1975 Sep;21(10):1498-505.
Direct iodination of morphine or dihydromorphine with iodine-125 results in products that bind to antibody raised by immunization of animals with a 3-O-carboxymethylmorphine/bovine serum albumin immunogen. Iodination of morphine or dihydromorphine with iodine-127 under identical conditions failed to yield these immunologically active products, suggesting that the results obtained with iodine-125 are in part due to a radiolytic reaction not observed with the iodine-127.
用碘 - 125对吗啡或二氢吗啡进行直接碘化反应，会生成能与用3 - O - 羧甲基吗啡/牛血清白蛋白免疫原免疫动物所产生的抗体相结合的产物。在相同条件下用碘 - 127对吗啡或二氢吗啡进行碘化反应，未能产生这些具有免疫活性的产物，这表明用碘 - 125得到的结果部分归因于碘 - 127未观察到的辐射分解反应。
