Corey E J, Zhang J
Department of Chemistry and Chemical Biology Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Org Lett. 2001 Oct 4;3(20):3211-4. doi: 10.1021/ol016577i.
[structure: see text] The chiral monocinchona derivative shown, synthesized in one step from two efficiently prepared chiral building blocks, was designed under mechanistic guidance as a catalyst for the enantio- and position-selective dihydroxylation of the terminal isopropylidene group of polyisoprenoids. Its efficacy as a synthetic reagent for this purpose was demonstrated for several different substrates.
[结构：见正文] 所示的手性单金鸡纳生物碱衍生物由两个高效制备的手性砌块一步合成，在机理指导下设计为聚异戊二烯末端异亚丙基的对映选择性和位置选择性二羟基化反应的催化剂。针对几种不同底物证明了其作为用于此目的的合成试剂的有效性。
