一种短不对称途径合成溴藻酚 A 和 D 骨架。
A short asymmetric route to the bromophycolide A and D skeleton.
机构信息
Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, USA.
出版信息
Org Lett. 2011 Mar 4;13(5):1222-5. doi: 10.1021/ol200099n. Epub 2011 Feb 10.
Abstract
An asymmetric synthesis of the bromophycolide D ring system has been achieved in seven steps from a known geranylgeranylated benzoate, via bromonium-promoted transannular cyclization of a macrocyclic intermediate.
摘要
已通过溴翁促进的大环中间体的反环化反应，从已知的香叶基香叶基化苯甲酸酯出发，经 7 步反应，实现了溴藻酚 D 环系的不对称合成。
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