Watanabe Y, Ueda H, Nakajima H, Minoura R, Hoshiai H, Noda K
Department of Obstetrics and Gynecology, Kinki University School of Medicine, Osaka, Japan.
Acta Cytol. 2001 Sep-Oct;45(5):756-60. doi: 10.1159/000328299.
Malignant melanoma arising in a cystic teratoma is extremely rare. We report the clinicopathologic and cytopathologic features of an amelanotic malignant melanoma arising in an ovarian cystic teratoma.
A 55-year-old woman presented with an asymptomatic right ovarian mass, showing features of cystic teratoma according to preoperative computed tomography and magnetic resonance imaging. The resected teratoma was suspected to include a nonepithelial malignancy in a touch preparation from a solid component. The tumor showed immunoreactivity for Melan-A, S-100 and HMB-45 in the absence of melanin granules, which established the diagnosis of amelanotic malignant melanoma arising in an ovarian cystic teratoma.
Cytopathologic findings from touch preparations and immunohistochemical staining are useful for the diagnosis of amelanotic malignant melanoma arising in an ovarian cystic teratoma.
囊性畸胎瘤中发生的恶性黑色素瘤极为罕见。我们报告一例卵巢囊性畸胎瘤中发生的无色素性恶性黑色素瘤的临床病理及细胞病理特征。
一名55岁女性因无症状的右侧卵巢肿块就诊，术前计算机断层扫描和磁共振成像显示为囊性畸胎瘤特征。切除的畸胎瘤在固体成分的触片标本中怀疑包含非上皮性恶性肿瘤。肿瘤在无黑色素颗粒的情况下对Melan-A、S-100和HMB-45呈免疫反应，从而确立了卵巢囊性畸胎瘤中发生的无色素性恶性黑色素瘤的诊断。
触片标本的细胞病理发现及免疫组化染色对卵巢囊性畸胎瘤中发生的无色素性恶性黑色素瘤的诊断有用。
