Seppänen M, Lokki M L, Timonen T, Lappalainen M, Jarva H, Järvinen A, Sarna S, Valtonen V, Meri S
Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital Helsinki, Finland.
Clin Infect Dis. 2001 Nov 1;33(9):1604-7. doi: 10.1086/323462. Epub 2001 Sep 26.
Three consecutive patients with no apparent immunodeficiency who had frequent intraoral herpes simplex type 1 recurrences, a rare complication of herpes simplex virus infection, were found to have a total deficiency of either the A or B isotype of the complement component C4 and to be homozygous for the studied HLA antigens. A combination of HLA homozygosity, which may lead to impaired T cell recognition of viral peptides, and deficiency in the classical complement pathway, which can compromise virus neutralization, may predispose to severe and frequent herpes simplex virus infections.
三名无明显免疫缺陷但频繁发生口腔单纯疱疹病毒1型复发（单纯疱疹病毒感染的一种罕见并发症）的连续患者，被发现补体成分C4的A或B同种型完全缺乏，并且在所研究的HLA抗原方面是纯合子。HLA纯合性可能导致T细胞对病毒肽的识别受损，而经典补体途径的缺陷可能会影响病毒中和，这两者的结合可能易患严重且频繁的单纯疱疹病毒感染。
