通过淋巴细胞和巨噬细胞进行克氏锥虫保护性免疫的过继转移。
Adoptive transfer of protection against Trypanosoma cruzi with lymphocytes and macrophages.
作者信息
Burgess D E, Hanson W L
出版信息
Infect Immun. 1979 Sep;25(3):838-43. doi: 10.1128/iai.25.3.838-843.1979.
Abstract
Female C57BL/6J mice were infected with Trypanosoma cruzi and subsequently given macrophages or lymphocytes from syngeneic donors which had recovered from the acute infection. Mice which received immune peritoneal macrophages, splenic lymphocytes, or lymph node lymphocytes developed lower mean parasitemias and cumulative mortalities than did recipients of nonimmune cells. Neither peritoneal lymphocytes nor splenic macrophages were protective, however. These studies indicate that splenic and lymph node lymphocytes are effective in transferring protection against T. cruzi, whereas the macrophage is somewhat less effective.
摘要
雌性C57BL/6J小鼠感染克氏锥虫，随后给予来自同基因供体且已从急性感染中恢复的巨噬细胞或淋巴细胞。接受免疫腹膜巨噬细胞、脾淋巴细胞或淋巴结淋巴细胞的小鼠，其平均寄生虫血症和累积死亡率低于接受非免疫细胞的小鼠。然而，腹膜淋巴细胞和脾巨噬细胞均无保护作用。这些研究表明，脾和淋巴结淋巴细胞在传递抗克氏锥虫的保护作用方面有效，而巨噬细胞的效果则稍差。
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本文引用的文献
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Connective tissue reactions in normal and immunized mice to a reticulotropic strain of Trypanosoma cruzi.正常和免疫小鼠对克氏锥虫网状嗜性菌株的结缔组织反应。
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