Al-Inany H G
Department of Obstetrics & Gynecology, Kasr El-Aini Hospital, Cairo University, Cairo, Egypt.
Acta Obstet Gynecol Scand. 2001 Oct;80(10):878-82. doi: 10.1034/j.1600-0412.2001.801002.x.
Severe OHSS is an iatrogenic, potentially life-threatening complication of controlled ovarian hyperstimulation. Intravenous human albumin, administered around the time of oocyte retrieval has been claimed to prevent development of this serious event. It was hypothesized that albumin acts through its osmotic pressure and through the binding and inactivation, at a critical time of the cycle, of an hCG-mediated factor secreted by the corpora lutea, that impedes capillary integrity and leads to the development of OHSS. The present article evaluates the available evidence in the medical literature whether albumin is effective in reducing the risk of severe OHSS. Several trials have been identified, most of them were retrospective and few were prospective randomized controlled trials. Although albumin prophylaxis cannot offer absolute protection, all three randomized placebo-controlled trials, that have been published so far, demonstrated a significant reduction in the incidence of severe OHSS.
重度卵巢过度刺激综合征（OHSS）是控制性卵巢刺激的一种医源性、潜在危及生命的并发症。在取卵前后静脉输注人白蛋白被认为可预防这一严重事件的发生。据推测，白蛋白通过其渗透压起作用，并在月经周期的关键时期结合并灭活由黄体分泌的一种人绒毛膜促性腺激素（hCG）介导的因子，该因子会破坏毛细血管完整性并导致OHSS的发生。本文评估了医学文献中关于白蛋白是否能有效降低重度OHSS风险的现有证据。已确定了多项试验，其中大多数是回顾性的，前瞻性随机对照试验较少。尽管白蛋白预防不能提供绝对保护，但迄今为止已发表的三项随机安慰剂对照试验均表明，重度OHSS的发生率显著降低。
