Mukherjee T, Copperman A B, Sandler B, Bustillo M, Grunfeld L
Department of Obstetrics and Gynecology, Mount Sinai Medical Center, New York, New York 10029.
Fertil Steril. 1995 Sep;64(3):641-3. doi: 10.1016/s0015-0282(16)57806-6.
To report two cases of severe ovarian hyperstimulation syndrome (OHSS) despite the administration of 50 g IV albumin at the time of oocyte retrieval. Two previous published series failed to observe OHSS in patients receiving prophylactic IV albumin.
Case reports of two women undergoing controlled ovarian hyperstimulation with E2 > 4,500 pg/mL (conversion factor to SI unit, 3.671) on the day of hCG administration who developed OHSS despite prophylactic albumin administration.
The division of reproductive endocrinology at the Mount Sinai Medical Center.
Fifty grams IV albumin (200 mL of a 25% albumin solution) were administered over 30 minutes at the time of oocyte retrieval.
Prevention of interstitial fluid accumulation such as ascites, pleural effusions, and generalized edema. The other goals of albumin administration included avoiding hemoconcentration, renal insufficiency, and thrombotic complications.
The patients developed sequelae of severe OHSS requiring hospitalization, despite administration of IV albumin.
Albumin is a promising agent in the prevention of OHSS. However, until the basic pathophysiology of this disorder can be elucidated, the mechanism of its action will remain elusive. Attempts to quantify and report clinical outcomes and the ultimate completion of a prospective randomized study will assist in the prevention and management of this enigmatic disorder.
报告两例尽管在取卵时静脉注射了50 g白蛋白仍发生严重卵巢过度刺激综合征（OHSS）的病例。之前发表的两个系列研究均未观察到接受预防性静脉注射白蛋白的患者发生OHSS。
两例接受控制性卵巢刺激的女性的病例报告，在注射人绒毛膜促性腺激素（hCG）当天雌二醇（E2）>4500 pg/mL（转换为国际单位制的换算系数为3.671），尽管给予了预防性白蛋白治疗，但仍发生了OHSS。
西奈山医学中心生殖内分泌科。
在取卵时30分钟内静脉注射50 g白蛋白（200 mL 25%的白蛋白溶液）。
预防间质液积聚，如腹水、胸腔积液和全身性水肿。白蛋白给药的其他目标包括避免血液浓缩、肾功能不全和血栓形成并发症。
尽管给予了静脉注射白蛋白，患者仍出现了严重OHSS的后遗症，需要住院治疗。
白蛋白是预防OHSS的一种有前景的药物。然而，在阐明该疾病的基本病理生理学之前，其作用机制仍将难以捉摸。尝试量化和报告临床结果以及前瞻性随机研究的最终完成将有助于预防和管理这种神秘的疾病。
