Fisher R S, Boden G
Gastroenterology. 1975 Sep;69(3):591-7.
To investigate both the cause and reversibility of pyloric sphincter dysfunction in patients with gastric ulcer, pyloric sphincter pressures were measured in 10 normal subjects and 13 patients with gastric ulcer before and during gastric acidification. Fasting serum gastrin concentration was significantly higher in patients with gastric ulcer than in normal subjects. Compared to normals, patients with gastric ulcer had significantly lower pyloric pressures in response to intraduodenal amino acids and sodium oleate. However, during gastric acidification, these same patients demonstrated normal pyloric responses to these stimuli. Serum gastrin concentrations did not change during gastric acidification. These studies show that: (1) in patients with gastric ulcer the pyloric sphincter does not respond normally to intraduodenal stimulation; (2) fasting serum gastrin concentration is elevated in patients with gastric ulcer; and (3) in these patients, pyloric sphincter dysfunction can be reversed by gastric acidification. The mechanism of pyloric dysfunction in patients with gastric ulcer remains unknown.
为了研究胃溃疡患者幽门括约肌功能障碍的病因及可逆性，我们对10名正常受试者和13名胃溃疡患者在胃酸化前后测量了幽门括约肌压力。胃溃疡患者空腹血清胃泌素浓度显著高于正常受试者。与正常人相比，胃溃疡患者对十二指肠内氨基酸和油酸钠的反应中幽门压力显著降低。然而，在胃酸化过程中，这些患者对这些刺激表现出正常的幽门反应。胃酸化过程中血清胃泌素浓度未发生变化。这些研究表明：（1）胃溃疡患者幽门括约肌对十二指肠内刺激反应不正常；（2）胃溃疡患者空腹血清胃泌素浓度升高；（3）在这些患者中，幽门括约肌功能障碍可通过胃酸化逆转。胃溃疡患者幽门功能障碍的机制尚不清楚。
