神经单相和双相电刺激分析

Analysis of monophasic and biphasic electrical stimulation of nerve.

作者信息

Rubinstein J T, Miller C A, Mino H, Abbas P J

机构信息

Department of Otolaryngology, University of Iowa, Iowa City 52242, USA.

出版信息

IEEE Trans Biomed Eng. 2001 Oct;48(10):1065-70. doi: 10.1109/10.951508.

DOI:10.1109/10.951508

PMID:11585029

Abstract

In an earlier study, biphasic and monphasic electrical stimulation of the auditory nerve was performed in cats with a cochlear implant. Single-unit recordings demonstrated that spikes resulting from monophasic and biphasic stimuli have different thresholds and latencies. Monophasic thresholds are lower and latencies are shorter under cathodic stimulation. Results from stochastic simulations of a biophysical model of electrical stimulation are similar. A simple analysis of a linear, "integrate to threshold" membrane model accounts for the threshold and latency differences observed experimentally and computationally. Since biphasic stimuli are used extensively in functional electrical stimulation, this analysis greatly simplifies the biophysical interpretation of responses to clinically relevant stimuli by relating them to the responses obtained with monophasic stimuli.

摘要

在一项早期研究中，对植入人工耳蜗的猫进行了听神经的双相和单相电刺激。单单位记录表明，单相和双相刺激产生的尖峰具有不同的阈值和潜伏期。在阴极刺激下，单相阈值较低，潜伏期较短。电刺激生物物理模型的随机模拟结果与之相似。对线性“积分至阈值”膜模型的简单分析解释了实验和计算中观察到的阈值和潜伏期差异。由于双相刺激在功能性电刺激中广泛使用，该分析通过将其与单相刺激获得的反应相关联，极大地简化了对临床相关刺激反应的生物物理解释。