Calonge M
Instituto Universitario de Oftalmobiologia Aplicada (IOBA), University of Valladolid, Spain.
Surv Ophthalmol. 2001 Mar;45 Suppl 2:S227-39. doi: 10.1016/s0039-6257(00)00205-8.
The most widely used therapy for dry eye disease is tear replacement by topical artificial tears. Punctal occlusion to prevent the drainage of natural or artificial tears is the most common non-pharmacological treatment. These and other traditional therapies for dry eye disease are only palliative, however, as they replace or conserve the tears without necessarily correcting the underlying disease process. As our understanding of the pathology of dry eye disease improves, new treatment strategies are being developed. Topical anti-inflammatory and immunomodulatory agents, such as cyclosporin A, are under investigation in the treatment of dry eye, as it is anticipated that they will correct the vicious cycle of inflammation and cell damage on the ocular surface and lacrimal glands.
治疗干眼症最广泛使用的方法是局部使用人工泪液来替代眼泪。泪点封闭以防止天然或人工泪液排出是最常见的非药物治疗方法。然而，这些以及其他治疗干眼症的传统疗法都只是姑息性的，因为它们只是替代或保存眼泪，而不一定纠正潜在的疾病过程。随着我们对干眼症病理的认识不断提高，新的治疗策略正在被开发出来。局部抗炎和免疫调节药物，如环孢素A，正在被研究用于治疗干眼症，因为预计它们将纠正眼表和泪腺炎症与细胞损伤的恶性循环。
