Shunk K A, Atalar E, Lima J A
Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Int J Cardiovasc Imaging. 2001 Jun;17(3):179-85. doi: 10.1023/a:1010667617641.
The thoracic aortic wall is a common site of atherosclerotic plaque in humans. Tools for serial, non-invasive assessment of these plaques are of value for addressing gaps in our basic understanding of the biology of plaque rupture and its relationship to atherosclerotic disease progression as well as for monitoring response to anti-atherosclerotic interventions in therapeutic clinical trials. Common approaches to assessment of the wall of the thoracic aorta in vivo are limited. Here we discuss some of the challenges and limitations encountered by conventional techniques and review a novel approach, transesophageal MRI (TEMRI). Initial experiences in applying the TEMRI approach to assessment of aortic morphology and pathology are discussed.
胸主动脉壁是人类动脉粥样硬化斑块的常见部位。用于对这些斑块进行连续、非侵入性评估的工具，对于填补我们对斑块破裂生物学及其与动脉粥样硬化疾病进展关系的基本认识空白，以及在治疗性临床试验中监测抗动脉粥样硬化干预措施的反应具有重要价值。体内评估胸主动脉壁的常用方法存在局限性。在此，我们讨论传统技术所面临的一些挑战和局限性，并回顾一种新方法——经食管磁共振成像（TEMRI）。还将讨论应用TEMRI方法评估主动脉形态和病理的初步经验。
