甲状腺上皮紧密连接随甲状腺活动变化而发生的改变。
Changes in tight junctions of thyroid epithelium with changes in thyroid activity.
作者信息
Tice L W, Wollman S H, Carter R C
出版信息
J Cell Biol. 1975 Sep;66(3):657-63. doi: 10.1083/jcb.66.3.657.
Abstract
The morphology of the tight junction of rat thyroid epithelium was examined in freeze-fractured material fixed in glutaraldehyde and briefly glycerinated. In normal thyroids the overall appearance of this junctional specialization resembled that of other cell types in many respects. Short-term changes in thyroid activity and hypophysectomy for 3 wk did not obviously affect the appearance of tight junctions. Feeding of the goitrogen, thiouracil, which stimulates secretion of thyroid-stimulating hormone, resulted in the appearance of some very narrow and some very wide, tight junctions or sometimes junctions with both wide and narrow regions within the same cell.
摘要
在经戊二醛固定并短暂甘油处理的冷冻断裂材料中，研究了大鼠甲状腺上皮紧密连接的形态。在正常甲状腺中，这种连接特化的整体外观在许多方面类似于其他细胞类型。甲状腺活性的短期变化以及垂体切除3周并未明显影响紧密连接的外观。喂食促甲状腺素分泌的致甲状腺肿物质硫脲后，出现了一些非常狭窄和一些非常宽阔的紧密连接，有时在同一细胞内还出现了既有宽阔区域又有狭窄区域的连接。
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