Tice L W, Wollman S H, Carter R C
J Cell Biol. 1975 Sep;66(3):657-63. doi: 10.1083/jcb.66.3.657.
The morphology of the tight junction of rat thyroid epithelium was examined in freeze-fractured material fixed in glutaraldehyde and briefly glycerinated. In normal thyroids the overall appearance of this junctional specialization resembled that of other cell types in many respects. Short-term changes in thyroid activity and hypophysectomy for 3 wk did not obviously affect the appearance of tight junctions. Feeding of the goitrogen, thiouracil, which stimulates secretion of thyroid-stimulating hormone, resulted in the appearance of some very narrow and some very wide, tight junctions or sometimes junctions with both wide and narrow regions within the same cell.
在经戊二醛固定并短暂甘油处理的冷冻断裂材料中，研究了大鼠甲状腺上皮紧密连接的形态。在正常甲状腺中，这种连接特化的整体外观在许多方面类似于其他细胞类型。甲状腺活性的短期变化以及垂体切除3周并未明显影响紧密连接的外观。喂食促甲状腺素分泌的致甲状腺肿物质硫脲后，出现了一些非常狭窄和一些非常宽阔的紧密连接，有时在同一细胞内还出现了既有宽阔区域又有狭窄区域的连接。
