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[瘢痕疙瘩和增生性瘢痕中转化生长因子-β1及Ⅰ型、Ⅲ型前胶原基因表达的变化]

[Changes in TGF-beta 1 and type I, III procollagen gene expression in keloid and hypertrophic scar].

作者信息

Tang S, Pang S, Cao Y

机构信息

Department of Burn and Plastic Surgery, Second Affiliated Hospital of Shantou University Medical College, Shantou 515041.

出版信息

Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1999 Jul;15(4):283-5.

PMID:11593607
Abstract

OBJECTIVE

The expression of mRNA for TGF-beta 1, type I, III procollagen in keloid and hypertrophic scar was investigated in order to elucidate the pathogenesis of and the difference between keloid and hypertrophic scar.

METHOD

Dot-blot hybridization analysis was used to examine the type I, III procollagen and the expression levels of steady-state mRNA. In situ hybridization allowed direct assessment of the distribution of TGF-beta 1 mRNA in the tissue.

RESULTS

  1. Our study indicated that the expression level of mRNA for TGF-beta 1 significantly increased in keloid and hypertrophic scar compared with normal scar and normal skin. 2. In keloid tissues, type I precollagen mRNA expression was selectively increased. However, in hypertrophic scar, type I and III collagen mRNAs expressions were simultaneously increased.

CONCLUSION

TGF-beta 1 plays an important role in the pathogenesis of keloid and hypertrophic scarring. It implicates that distinct molecular mechanisms are operative in the development of keloid and hypertrophic scarring.

摘要

目的

研究瘢痕疙瘩和增生性瘢痕中转化生长因子-β1（TGF-β1）、Ⅰ型和Ⅲ型前胶原mRNA的表达情况，以阐明瘢痕疙瘩和增生性瘢痕的发病机制及两者之间的差异。

方法

采用斑点杂交分析法检测Ⅰ型、Ⅲ型前胶原及稳态mRNA的表达水平。原位杂交可直接评估组织中TGF-β1 mRNA的分布。

结果

  1. 我们的研究表明，与正常瘢痕和正常皮肤相比，瘢痕疙瘩和增生性瘢痕中TGF-β1 mRNA的表达水平显著升高。2. 在瘢痕疙瘩组织中，Ⅰ型前胶原mRNA表达选择性增加。然而，在增生性瘢痕中，Ⅰ型和Ⅲ型胶原mRNA表达同时增加。

结论

TGF-β1在瘢痕疙瘩和增生性瘢痕形成的发病机制中起重要作用。这表明瘢痕疙瘩和增生性瘢痕形成过程中存在不同的分子机制。

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