氧化应激与骨密度之间的关联。

Association between oxidative stress and bone mineral density.

作者信息

Basu S, Michaëlsson K, Olofsson H, Johansson S, Melhus H

机构信息

Sections of Geriatrics and Clinical Nutrition Research, Uppsala University Hospital, S-751 25 Uppsala, Sweden.

出版信息

Biochem Biophys Res Commun. 2001 Oct 19;288(1):275-9. doi: 10.1006/bbrc.2001.5747.

DOI:10.1006/bbrc.2001.5747

PMID:11594785

Abstract

Free radicals have been shown to be involved in bone resorption in vitro and in rodents. We studied the effect of oxidative stress on bone mineral density (BMD) in 48 women and 53 men from a population-based study. The levels of 8-iso-PGF(2alpha) (a major F(2)-isoprostane and a biomarker of oxidative stress) and a control, 15-keto-dihydro-PGF(2alpha) (a biomarker of inflammatory response), were measured in urinary samples and their association with BMD and quantitative ultrasound (QUS) measurements were examined. In multivariate linear regression analyses, 8-iso-PGF(2alpha) levels were negatively associated with both BMD and QUS. In contrast, no association was found for 15-keto-dihydro-PGF(2alpha). Our findings establish a biochemical link between increased oxidative stress and reduced bone density and provide a rational for further studies investigating the role of pro- and antioxidants in osteoporosis.

摘要

自由基已被证明在体外实验和啮齿动物实验中参与骨吸收过程。在一项基于人群的研究中，我们对48名女性和53名男性进行了研究，以探讨氧化应激对骨密度（BMD）的影响。检测了尿样中8-异前列腺素F2α（一种主要的F2-异前列腺素，也是氧化应激的生物标志物）以及对照物15-酮二氢前列腺素F2α（炎症反应的生物标志物）的水平，并研究了它们与骨密度和定量超声（QUS）测量值之间的关联。在多变量线性回归分析中，8-异前列腺素F2α水平与骨密度和定量超声均呈负相关。相比之下，未发现15-酮二氢前列腺素F2α与骨密度和定量超声之间存在关联。我们的研究结果在氧化应激增加与骨密度降低之间建立了生化联系，并为进一步研究促氧化剂和抗氧化剂在骨质疏松症中的作用提供了理论依据。