Sugawa-Katayama Y, Morita N
J Nutr. 1977 Apr;107(4):534-8. doi: 10.1093/jn/107.4.534.
The effect of a high fructose diet on lipogenic enzyme activities in liver, intestine and adipose tissue, and serum immunoreactive insulin level was studied in meal-fed rats. Male and female rats were meal-fed for 5 days with stock diet. After a 45-hour fast, they were meal-fed a high carbohydrate diet composed of fructose, glucose or cornstarch diet for 4 days. The daily food intake was similar within each sex (females 9-11 g/day and males 10-13 g/day). Only males fed glucose consumed significantly more food than any other group (12.9 g/day). Rats fed fructose had the greatest liver weight and total lipid content. The hepatic malic enzyme activity of both sexes was significantly higher in rats fed fructose than in those fed cornstarch. Small intestinal malic enzyme activity was largely unaffected by diet. The serum immunoreactive insulin level of rats fed fructose was the lowest, and the level in females was higher than in males fed fructose or glucose. The above results lead to the conclusion that the effect of feeding fructose compared to glucose is attributable to fructose itself and not differences in food intake.
在按餐喂养的大鼠中，研究了高果糖饮食对肝脏、肠道和脂肪组织中脂肪生成酶活性以及血清免疫反应性胰岛素水平的影响。雄性和雌性大鼠用基础饲料按餐喂养5天。禁食45小时后，它们按餐喂养由果糖、葡萄糖或玉米淀粉组成的高碳水化合物饮食4天。每个性别内的每日食物摄入量相似（雌性9 - 11克/天，雄性10 - 13克/天）。只有喂食葡萄糖的雄性大鼠比其他任何组消耗的食物明显更多（12.9克/天）。喂食果糖的大鼠肝脏重量和总脂质含量最高。喂食果糖的大鼠两性的肝脏苹果酸酶活性显著高于喂食玉米淀粉的大鼠。小肠苹果酸酶活性在很大程度上不受饮食影响。喂食果糖的大鼠血清免疫反应性胰岛素水平最低，且雌性大鼠的该水平高于喂食果糖或葡萄糖的雄性大鼠。上述结果得出结论，与葡萄糖相比，喂食果糖的影响归因于果糖本身而非食物摄入量的差异。
